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ELISA Kit for Rat Ubiquitin D

SKU : BHE13810919

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1744r
Alternative Names	Diubiquitin ; Ubiquitin-like protein FAT10 ; Fat10
Categories	Elisa
Function	Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases.
Specificity	Natural and recombinant Rat Ubiquitin D
Subcellular Location	Nucleus Cytoplasm Accumulates in aggresomes under proteasome inhibition conditions.
Detection Range	0.156-10ng/mL
Entryname	UBD_RAT
Method Type	Sandwich
Platform	PF00240
Protein Name	Ubiquitin D
Sensitivity	0.084ng/mL
Sequence	50: MASCVCVVRS ; EQWPLMTFDT ; TMSDKVKKIN ; EHIRSQTKVS ; VQDQILLLDS ; 100: KILKPHRALS ; SYGIDKENTI ; HLTLKVVKPS ; DEELPLSLVE ; SGDEGQRHLL ; 150: RVRRSSSVAQ ; VKEMIENVTA ; VPPKKQIVNC ; NGKRLEDGKI ; MADYNIKSGS ; 161: LLFLTAHCIG ; G
Sequence Length	161
String	Q921A3
Sub Unit	Interact directly with the 26S proteasome. The interaction with NUB1L vie the N-terminal ubiquitin domain facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own degradation and that of its conjugates. Interacts with the spindle checkpoint protein MAD2L1 during mitosis. Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions. Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg).

Uniprot	Q921A3
Gene Name	Ubd
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29168
Unigene	Rn.18473

Reference	1. "Characterization of the rat Ubd gene." Walter L. Submitted (2001-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "The genomic sequence and comparative analysis of the rat major histocompatibility complex." Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H. Genome Res.14:631-639(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: Brown Norway.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810919	E1744r	96T	$796		Add to Cart

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