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ELISA Kit for Rat Slit homolog 2 protein

SKU : BHE13810886

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0672r
Categories	Elisa
Function	Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. Seems to be involved in regulating leukocyte migration.
Specificity	Natural and recombinant Rat Slit homolog 2 protein
Subcellular Location	Secreted
Detection Range	0.312-20ng/mL
Entryname	SLIT2_RAT
Method Type	Sandwich
Platform	PF00560
Protein Name	Slit homolog 2 protein
Sensitivity	0.167ng/mL
Sequence	50: MSGIGWQTLS ; LSLALVLSIL ; NKVAPHACPA ; QCSCSGSTVD ; CHGLALRIVP ; 100: RNIPRNTERL ; DLNGNNITRI ; TKTDFAGLRH ; LRILQLMENK ; ISTIERGAFH ; 150: DLKELERLRL ; NRNNLQLFPE ; LLFLGTAKLY ; RLDLSENQIQ ; AIPRKAFRGA ; 200: VDIKNLQLDY ; NQISCIEDGA ; FRALRDLEVL ; TLNNNNITRL ; SVASFNHMPK ; 250: LRTFRLHSNN ; LYCDCHLAWL ; SDWLRQRPRV ; GLYTQCMGPS ; HLRGHNVAEV ; 300: QKREFVCSDE ; EEGHQSFMAP ; SCSVLHCPIA ; CTCSNNIVDC ; RGKGLTEIPT ; 350: NLPETITEIR ; LEQNSIRVIP ; PGAFSPYKKL ; RRLDLSNNQI ; SELAPDAFQG ; 400: LRSLNSLVLY ; GNKITELPKS ; LFEGLFSLQL ; LLLNANKINC ; LRVDAFQDLH ; 450: NLNLLSLYDN ; KLQTVAKGTF ; SALRAIQTMH ; LAQNPFICDC ; HLKWLADYLH ; 500: TNPIETSGAR ; CTSPRRLANK ; RIGQIKSKKF ; RCSGTEDYRS ; KLSGDCFADL ; 550: ACPEKCRCEG ; TTVDCSNQKL ; NKIPDHIPQY ; TAELRLNNNE ; FTVLEATGIF ; 600: KKLPQLRKIN ; LSNNKITDIE ; EGAFEGASGV ; NEILLTSNRL ; ENVQHKMFKG ; 650: LESLKTLMLR ; SNRISCVGND ; SFTGLGSVRL ; LSLYDNQITT ; VAPGAFGTLH ; 700: SLSTLNLLAN ; PFNCNCHLAW ; LGEWLRRKRI ; VTGNPRCQKP ; YFLKEIPIQD ; 750: VAIQDFTCDD ; GNDDNSCSPL ; SRCPSECTCL ; DTVVRCSNKG ; LKVLPKGIPR ; 766: DVTELYLDGN ; QFTLVP
Sequence Length	766
String	Q9WVC1
Sub Unit	Homodimer. Binds ROBO1 and ROBO2 with high affinity (By similarity). Interacts with GREM1.

Uniprot	Q9WVC1
Gene Name	Slit2
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.146652

Reference	1. "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain." Liang Y., Annan R.S., Carr S.A., Popp S., Mevissen M., Margolis R.K., Margolis R.U. J. Biol. Chem.274:17885-17892(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. 2. "Spatiotemporal expression patterns of slit and robo genes in the rat brain." Marillat V., Cases O., Nguyen-Ba-Charvet K.T., Tessier-Lavigne M., Sotelo C., Chedotal A. J. Comp. Neurol.442:130-155(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE 3. "Bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis." Chen B., Blair D.G., Plisov S., Vasiliev G., Perantoni A.O., Chen Q., Athanasiou M., Wu J.Y., Oppenheim J.J., Yang D. J. Immunol.173:5914-5917(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GREM1

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