ELISA Kit for Rat Protransforming growth factor alpha

Mfr.No.	E0123r
Categories	Elisa
Function	TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Specificity	Natural and recombinant Rat Protransforming growth factor alpha
Subcellular Location	Protransforming growth factor alpha Cell membrane Single-pass type I membrane protein
Detection Range	31.2-2000pg/mL
Entryname	TGFA_RAT
Method Type	Sandwich
Protein Name	Protransforming growth factor alpha
Sensitivity	15.79pg/mL
Sequence	50: MVPAAGQLAL ; LALGILVAVC ; QALENSTSPL ; SDSPVAAAVV ; SHFNKCPDSH ; 100: TQYCFHGTCR ; FLVQEEKPAC ; VCHSGYVGVR ; CEHADLLAVV ; AASQKKQAIT ; 150: ALVVVSIVAL ; AVLIITCVLI ; HCCQVRKHCE ; WCRALVCRHE ; KPSALLKGRT ; 159: ACCHSETVV
Sequence Length	159
String	P01134
Sub Unit	Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2.

Reference	1. "Cloning and sequence analysis of a cDNA for rat transforming growth factor-alpha." Lee D.C., Rose T.M., Webb N.R., Todaro G.J. Nature313:489-491(1985) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Characterization of the rat transforming growth factor alpha gene and identification of promoter sequences." Blasband A.J., Rogers K.T., Chen X., Azizkhan J.C., Lee D.C. Mol. Cell. Biol.10:2111-2121(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] 3. "Rat transforming growth factor type 1: structure and relation to epidermal growth factor." Marquardt H., Hunkapiller M.W., Hood L.E., Todaro G.J. Science223:1079-1082(1984) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 39-88 4. "Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells." Massague J. J. Biol. Chem.258:13606-13613(1983) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 39-67

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