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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Linker for activation of T-cells family member 1

SKU : BHE13805678

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0270r
Alternative Names	36 kDa phospho-tyrosine adapter protein ; pp36 ; p36-38
Categories	Elisa
Function	Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Specificity	Natural and recombinant Rat Linker for activation of T-cells family member 1
Subcellular Location	Cell membrane Single-pass type III membrane protein Present in lipid rafts.
Detection Range	78-5000pg/mL
Entryname	LAT_RAT
Method Type	Sandwich
Platform	PF15234
Protein Name	Linker for activation of T-cells family member 1
Sensitivity	39pg/mL
Sequence	50: MEADALSPVE ; LGLLLLPFVV ; MLLAALCVRC ; RELPASYDSA ; STESLYPRSI ; 100: LIKPPQITVP ; RTPATSYPLV ; TSFPPLRQPD ; LLPIPRSPQP ; LGGSHRMPSS ; 150: RQNSDDANSV ; ASYENQEPAR ; KNVDEDEDED ; DYPEGYLVVL ; PDSSPAAVPV ; 200: VSSAPVPSNP ; DLGDSAFSME ; SCEDYVNVPE ; SEESAEASLD ; GSREYVNVSQ ; 241: DAQPVIRAEL ; ASVTSQEVED ; EEEEDVDGEE ; APDYENLQEL ; N
Sequence Length	241
String	O70601
Sub Unit	When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK. Interacts with FCGR1A.

Uniprot	O70601
Gene Name	Lat
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:81511
Unigene	Rn.9773

Reference	1. "Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells." Weber J.R., Orstavik S., Torgersen K.M., Danbolt N.C., Berg S.F., Ryan J.C., Tasken K., Imboden J.B., Vaage J.T. J. Exp. Med.187:1157-1161(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: PVG. tissue: Natural killer cell. 2. "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." Tedoldi S., Paterson J.C., Hansmann M.-L., Natkunam Y., Rudiger T., Angelisova P., Du M.Q., Roberton H., Roncador G., Sanchez L., Pozzobon M., Masir N., Barry R., Pileri S., Mason D.Y., Marafioti T., Horejsi V. Blood107:213-221(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805678	E0270r	96T	$796		Add to Cart

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