ELISA Kit for Rat Interleukin-1 alpha

Mfr.No.	E0071r
Categories	Elisa
Function	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Specificity	Natural and recombinant Rat Interleukin-1 alpha
Subcellular Location	Secreted The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Detection Range	15.6-1000pg/mL
Entryname	IL1A_RAT
Method Type	Sandwich
Platform	PF00340
Protein Name	Interleukin-1 alpha
Sensitivity	7.91pg/mL
Sequence	50: MAKVPDLFED ; LKNCYSENEE ; YSSAIDHLSL ; NQKSFYDASY ; GSLHENCTDK ; 100: FVSLRTSETS ; KMSTFTFKES ; RVVVSATSNK ; GKILKKRRLS ; FNQPFTEDDL ; 150: EAIAHDLEET ; IQPRSAPHSF ; QNNLRYKLIR ; IVKQEFIMND ; SLNQNIYVDM ; 200: DRIHLKAASL ; NDLQLEVKFD ; MYAYSSGGDD ; SKYPVTLKVS ; NTQLFVSAQG ; 250: EDKPVLLKEI ; PETPKLITGS ; ETDLIFFWEK ; INSKNYFTSA ; AFPELLIATK ; 270: EQSQVHLARG ; LPSMIDFQIS ;
Sequence Length	270
String	P16598
Sub Unit	Monomer.

Reference	1. "Molecular cloning and expression of rat interleukin-1 alpha cDNA." Nishida T., Nishino N., Takano M., Sekiguchi Y., Kawai K., Mizuno K., Nakai S., Masui Y., Hirai Y. J. Biochem.105:351-357(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Production of recombinant rat testis interleukin-1 alpha precursor form and discovery of a novel splice version lacking the calpain cleavage site." Sultana T., Svechnikov K., Weber G., Soeder O. Submitted (1999-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Testis.

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