Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP.
Specificity
Natural and recombinant Rat Insulin-degrading enzyme
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 42-1019 OF WILD TYPE AND MUTANT PHE-111;SUBUNIT;COFACTOR;ZINC-BINDING SITES;ENZYME REGULATION;ALLOSTERIC REGULATION
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS);ATP-BINDING SITE;MUTAGENESIS OF ARG-429; LYS-898; LYS-899 AND SER-901
Reviews of ELISA Kit for Rat Insulin-degrading enzyme