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ELISA Kit for Rat Endothelial PAS domain-containing protein 1

SKU : BHE13803588

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2004r
Alternative Names	Hypoxia-inducible factor 2-alpha ; HIF-2-alpha ; Hif2a
Categories	Elisa
Function	Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Specificity	Natural and recombinant Rat Endothelial PAS domain-containing protein 1
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	EPAS1_RAT
Method Type	Sandwich
Platform	PF11413
Protein Name	Endothelial PAS domain-containing protein 1
Sensitivity	0.085ng/mL
Sequence	50: MTADKEKKRS ; SSELRKEKSR ; DAARCRRSKE ; TEVFYELAHE ; LPLPHSVSSH ; 100: LDKASIMRLA ; ISFLRTHKLL ; SSVCSENESE ; AEADQQMDNL ; YLKALEGFIA ; 150: VVTQDGDMIF ; LSENISKFMG ; LTQVELTGHS ; IFDFTHPCDH ; EEIRENLTLK ; 200: TGSGFGKKNK ; DRSTERDFFM ; RMKCTVTNRG ; RTVNLKSATW ; KVLHCTGQVR ; 250: VYNNCPPHSS ; LCGYKEPLLS ; CLIIMCEPIQ ; HPSHMDIPLD ; SKTFLSRHSM ; 300: DMKFTYCDDR ; ILELVGYHPE ; ELLGRSAYEF ; YHALDSENMT ; KSHQNLCTKG ; 350: QVVSGQYRML ; AKHGGYVWLE ; TQGTVVYNPR ; NLQPQCIMCV ; NYVLSEIEKN ; 400: DVVVSMDQTE ; SCSSHTLMAM ; NSIFDTSDDV ; ALSEKSNYLF ; TNLKEEPEDL ; 450: AQLAPTPGDA ; IISLDFGSQN ; FDESSTYGKA ; ILPPGQPWAT ; ELRSHSAQSE ; 500: SRSLPAFTVP ; QAGSPGNATP ; SATSSSSCST ; PSSPEDYYSS ; LENHLKIEVI ; 550: EKLFAMDTEA ; KDQCSTQTDF ; NELDLETLAP ; YIPMDGEDFQ ; LSPICPEEPL ; 600: VPESPQPNPQ ; HCFSTMSSIF ; QPLTPGASQG ; TFFLDKYPQQ ; LESRKTESEH ; 650: WPMSTIFFDA ; GSKGSLPPCC ; GQASTPLSSM ; GGRSNTPWPP ; DPPLHLGPTK ; 700: WSVGNQSAEP ; LGPLPLGTSQ ; LEPPSTPPHV ; SMFKMRSAKD ; FGARGPYMMS ; 750: PAMIALSNKL ; KLKRQLDYEE ; PAFQDTSGGD ; PPGTSSSHLM ; WKRMKSLMGG ; 800: TCPLMPDKTV ; SASMAPDEFT ; QKSMRGLGQP ; LRHLPPSQPP ; STRSPGENAK ; 850: SGFPPQCYAS ; PFQDYSPPGA ; QKGSGVASRL ; LGPSFEPYLL ; PELTRYDCEV ; 874: NVPEPGSSTL ; LQGRDLLRAL ; DQAT
Sequence Length	874
String	Q9JHS1
Sub Unit	Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT.

Uniprot	Q9JHS1
Gene Name	Epas1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29452
Unigene	Rn.163791

Reference	1. "Perivenous expression of the mRNA of the three hypoxia-inducible factor a-subunits HIF-1a, HIF2a and HIF3a in rat liver." Kietzmann T., Cornesse Y., Brechtel K., Modaressi S., Jungermann K. Biochem. J.354:531-537(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Liver.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803588	E2004r	96T	$796		Add to Cart

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