Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Specificity
Natural and recombinant Rat Dual oxidase 1
Subcellular Location
Apical cell membrane Multi-pass membrane protein Localizes to the apical membrane of epithelial cells.