ELISA Kit for Rat Corticosteroid 11-beta-dehydrogenase isozyme 2

Mfr.No.	E11618r
Alternative Names	11-beta-hydroxysteroid dehydrogenase type 2 ; 11-DH2 ; NAD-dependent 11-beta-hydroxysteroid dehydrogenase ; Hsd11k
Categories	Elisa
Function	Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Specificity	Natural and recombinant Rat Corticosteroid 11-beta-dehydrogenase isozyme 2
Subcellular Location	Microsome Endoplasmic reticulum
Detection Range	0.156-10ng/mL
Entryname	DHI2_RAT
Method Type	Sandwich
Platform	PF00106
Protein Name	Corticosteroid 11-beta-dehydrogenase isozyme 2
Sensitivity	7.84pg/mL
Sequence	50: MERWPWPSGG ; AWLLVAARAL ; LQLLRSDLRL ; GRPLLAALAL ; LAALDWLCQR ; 100: LLPPPAALVV ; LAGAGWIALS ; RLARPPRLPV ; ATRAVLITGC ; DTGFGKETAK ; 150: KLDAMGFTVL ; ATVLDLNGPG ; ALELRARCSP ; RLKLLQMDLT ; KPEDISRVLE ; 200: ITKAHTASTG ; LWGLVNNAGL ; NMVVADVELS ; PVVTFRECME ; VNFFGALELT ; 250: KGLLPLLRHS ; RGRIVTVGSP ; AGDMPYPCLA ; AYGTSKAAIA ; LLMDTFSCEL ; 300: LPWGIKVSII ; QPGCFKTEAV ; TNVNLWEKRK ; QLLLANLPRE ; LLQAYGEDYI ; 350: EHLHGQFLNS ; LRMALPDLSP ; VVDAIIDALL ; AAQPRSRYYT ; GRGLGLMYFI ; 400:
Sequence Length	400
String	P50233
Sub Unit	Interacts with ligand-free cytoplasmic NR3C2.

Reference	1. "Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11 beta-hydroxysteroid dehydrogenase." Zhou M.-Y., Gomez-Sanchez E.P., Cox D.L., Cosby D., Gomez-Sanchez C.E. Endocrinology136:3729-3734(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Kidney. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Kidney. 3. Lubec G., Chen W.-Q. Submitted (2009-01) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-25;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Hippocampus.

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BHE13803331	E11618r	96T	$796		Add to Cart