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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig Interleukin-4 receptor subunit alpha

SKU : BHE13805100

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2031p
Alternative Names	CD124
Categories	Elisa
Function	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Specificity	Natural and recombinant Pig Interleukin-4 receptor subunit alpha
Subcellular Location	Membrane Single-pass type I membrane protein
Entryname	IL4RA_PIG
Platform	PF09238
Protein Name	Interleukin-4 receptor subunit alpha
Sequence	50: MGWLCPGLTF ; SVSCLILVWA ; AGSGVTCVSP ; GGVRVLEWPI ; CLSDYVSTST ; 100: CEWRMAGPVN ; CSAEFRLSYQ ; LKFFNTENHT ; TCVPENRAGS ; VCVCHMLMES ; 150: IVIVDTYQLD ; LWAGEQLLWN ; SSFKPSQNVK ; PLAPRNLMVH ; ANISHTWLLT ; 200: WSNPYPSESY ; LYSELTYLVN ; ISNENDPTDF ; RIYNVTYLGP ; TLRFPANTLK ; 250: SGAAYSARVK ; AWAQRYNSTW ; SEWSPSVKWL ; NYYEEPLEQR ; LPLGVSISCV ; 300: VILIICLSCY ; FGIIRIKKEW ; WDQIPNPAHS ; PLVAIVIQDS ; QVSLWGKRSR ; 350: GQEPAKCPRW ; KTCLTKLLPC ; FLEHGVDRDE ; DSSKAARNGP ; SQGPAKAAWR ; 400: PVEVSKTILW ; PESISVVRCV ; ELFEAQVENE ; EEEEEEDKGS ; FCPSPENSGG ; 450: SFQEGREGIA ; ARLTESLFLD ; LLGDESGAFS ; PQGMGQSCLL ; PPLENASAPM ; 500: PWAEFPRVGS ; PEASSQGKEQ ; PLNPEPSPQA ; TPTQSLASLA ; FPELPAVIAD ; 550: NPAYRSFSTF ; LSQSSDPGEL ; DSDPELAEAL ; EEVEPSLPAA ; PQPSEPPPTL ; 600: QPEPETWEQI ; LRQSVLQRRA ; APAPASGPSS ; SGYREFVHAV ; EQGTQDRRAA ; 650: GSGPCGEAGY ; KAFSSLLAGS ; ASCPGTSGLE ; PSSGESGYKP ; FQSLPPGCPE ; 700: TPVPTPLFTF ; GLDMEPPPSP ; QNPPFPGSSA ; ECPGLEPAVK ; GEDGQKPPLA ; 750: LEQAADPLRD ; DLGSGIVYSA ; LTCHLCGHLK ; QCHGQEDGGK ; VHVVASPCCS ; 800: CCCEDGSPPM ; VTPLRAPDAP ; SSGVPLEASL ; SPASLALLGV ; SREGKIPPCL ; 830: QITPSNVQSS ; SQTPTAVAML ; SPGPACMDTS ;
Sequence Length	830
Sub Unit	The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region (By similarity). In Th1 cells, binds the N-terminal 50AA of SOCS5, which inhibits JAK1 interaction, STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine phosphorylation.

Uniprot	Q863Z5
Gene Name	IL4R
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:397614
Unigene	Ssc.17244

Reference	1. "Molecular cloning of the swine IL-4 receptor alpha and IL-13 receptor alpha 1 chains: effects of experimental Toxoplasma gondii and Ascaris suum infections on tissue mRNA levels." Zarlenga D.S. Jr., Dawson H., Solano-Aguilar G., Urban J.F. Jr. Submitted (2003-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805100	E2031p	96T	$900		Add to Cart

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