NF-E2-inducible protein 2 ; Protein ni-2 ; Transmembrane protein 49 ; Tmem49
Categories
Elisa
Function
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (By similarity). Plays a role in the initial stages of the autophagic process through its interaction with BECN1.
Specificity
Natural and recombinant Mouse Vacuole membrane protein 1
Subcellular Location
Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Vacuole membrane Multi-pass membrane protein Endoplasmic reticulum