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ELISA Kit for Mouse Telomerase protein component 1

SKU : BHE13811416

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0558m
Alternative Names	Telomerase-associated protein 1 ; Telomerase protein 1 ; p240 ; p80 telomerase homolog ; Tp1
Categories	Elisa
Function	Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
Specificity	Natural and recombinant Mouse Telomerase protein component 1
Subcellular Location	Nucleus Chromosome telomere
Detection Range	0.78-50ng/mL
Entryname	TEP1_MOUSE
Method Type	Sandwich
Platform	PF13271
Protein Name	Telomerase protein component 1
Sensitivity	0.435ng/mL
Sequence	50: MEKLCGHVPG ; HSDILSLKNR ; CLTMLPDLQP ; LEKIHGHRSV ; HSDILSLENQ ; 100: CLTMLSDLQP ; TERIDGHISV ; HPDILSLENR ; CLTMLPDLQP ; LEKLCGHMSS ; 150: HPDVLSLENQ ; CLATLPTVKS ; TALTSPLLQG ; LHISHTAQAD ; LHSLKTSNCL ; 200: LPELPTKKTP ; CFSEELDLPP ; GPRALKSMSA ; TAQVQEVALG ; QWCVSKEKEF ; 250: QEEESTEVPM ; PLYSLSLEEE ; EVEAPVLKLT ; SGDSGFHPET ; TDQVLQEKKM ; 300: ALLTLLCSAL ; ASNVNVKDAS ; DLTRASILEV ; CSALASLEPE ; FILKASLYAR ; 350: QQLNLRDIAN ; TVLAVAALLP ; ACRPHVRRYY ; SAIVHLPSDW ; IQVAEFYQSL ; 400: AEGDEKKLVS ; LPACLRAAMT ; DKFAEFDEYQ ; LAKYNPRKHR ; SKRRSRQPPR ; 450: PQKTERPFSE ; RGKCFPKSLW ; PLKNEQITFE ; AAYNAMPEKN ; RLPRFTLKKL ; 500: VEYLHIHKPA ; QHVQALLGYR ; YPATLELFSR ; SHLPGPWESS ; RAGQRMKLRR ; 550: PETWERELSL ; RGNKASVWEE ; LIDNGKLPFM ; AMLRNLCNLL ; RTGISARHHE ; 600: LVLQRLQHEK ; SVVHSRQFPF ; RFLNAHDSID ; KLEAQLRSKA ; SPFPSNTTLM ; 650: KRIMIRNSKK ; NRRPASRKHL ; CTLTRRQLRA ; AMTIPVMYEQ ; LKREKLRLHK ; 700: ARQWNCDVEL ; LERYRQALET ; AVNLSVKHNL ; SPMPGRTLLV ; YLTDANADRL ; 750: CPKSHSQGPP ; LNYVLLLIGM ; MVARAEQVTV ; CLCGGGFVKT ; PVLTADEGIL ; 800: KTAIKLQAQV ; QELEGNDEWP ; LDTFGKYLLS ; LAVQRTPIDR ; VILFGQRMDT ; 850: ELLKVAKQII ; WQHVNSKCLF ; VGVLLQKTQY ; ISPNLNPNDV ; TLSGCTDGIL ; 900: KFIAEHGASR ; LLEHVGQLDK ; LFKIPPPPGK ; TQAPSLRPLE ; ENIPGPLGPI ; 950: SQHGWRNIRL ; FISSTFRDMH ; GERDLLMRSV ; LPALQARVFP ; HRISLHAIDL ; 1000: RWGITEEETR ; RNRQLEVCLG ; EVENSQLFVG ; ILGSRYGYIP ; PSYDLPDHPH ; 1050: FHWTHEYPSG ; RSVTEMEVMQ ; FLNRGQRSQP ; SAQALIYFRD ; PDFLSSVPDA ; 1100: WKPDFISESE ; EAAHRVSELK ; RYLHEQKEVT ; CRSYSCEWGG ; VAAGRPYTGG ; 1150: LEEFGQLVLQ ; DVWSMIQKQH ; LQPGAQLEQP ; TSISEDDLIQ ; TSFQQLKTPT ; 1200: SPARPRLLQD ; TVQQLLLPHG ; RLSLVTGQAG ; QGKTAFLASL ; VSALKVPDQP ; 1250: NEPPFVFFHF ; AAARPDQCLA ; LNLLRRLCTH ; LRQKLGELSA ; LPSTYRGLVW ; 1300: ELQQKLLLKF ; AQSLQPAQTL ; VLIIDGADKL ; VDRNGQLISD ; WIPKSLPRRV ; 1350: HLVLSVSSDS ; GLGETLQQSQ ; GAYVVALGSL ; VPSSRAQLVR ; EELALYGKRL ; 1400: EESPFNNQMR ; LLLAKQGSSL ; PLYLHLVTDY ; LRLFTLYEQV ; SERLRTLPAT ; 1450: LPLLLQHILS ; TLEQEHGHDV ; LPQALTALEV ; TRSGLTVDQL ; HAILSTWLIL ; 1500: PKETKSWEEV ; LAASHSGNPF ; PLCPFAYLVQ ; SLRSLLGEGP ; VERPGARLCL ; 1550: SDGPLRTTIK ; RRYGKRLGLE ; KTAHVLIAAH ; LWKTCDPDAS ; GTFRSCPPEA ; 1600: LKDLPYHLLQ ; SGNHGLLAEF ; LTNLHVVAAY ; LEVGLVPDLL ; EAHVLYASSK ; 1650: PEANQKLPAA ; DVAVFHTFLR ; QQASLLTQYP ; LLLLQQAASQ ; PEESPVCCQA ; 1700: PLLTQRWHDQ ; FTLKWINKPQ ; TLKGQQSLSL ; TMSSSPTAVA ; FSPNGQRAAV ; 1750: GTASGTIYLL ; NLKTWQEEKA ; VVSGCDGISS ; FAFLSDTALF ; LTTFDGHLEL ; 1800: WDLQHGCWVF ; QTKAHQYQIT ; GCCLSPDRRL ; LATVCLGGYL ; KLWDTVRGQL ; 1850: AFQYTHPKSL ; NCVAFHPEGQ ; VVATGSWAGS ; ITFFQADGLK ; VTKELGAPGP ; 1900: SVCSLAFNKP ; GKIVAVGRID ; GTVELWAWQE ; GARLAAFPAQ ; CGCVSAVLFL ; 1950: HAGDRFLTAG ; EDGKAQLWSG ; FLGRPRGCLG ; SLPLSPALSV ; ALNPDGDQVA ; 2000: VGYREDGINI ; YKISSGSQGP ; QHQELNVAVS ; ALVWLSPSVL ; VSGAEDGSLH ; 2050: GWMFKGDSLH ; SLWLLSRYQK ; PVLGLAASRE ; LMAAASEDFT ; VRLWPRQLLT ; 2100: QPHVHAVELP ; CCAELRGHEG ; PVCCCSFSPD ; GGILATAGRD ; RNLLCWDMKI ; 2150: AQAPLLIHTF ; SSCHRDWITG ; CAWTKDNILV ; SCSSDGSVGL ; WNPEAGQQLG ; 2200: QFSGHQSAVS ; AVVAVEEHIV ; SVSRDGTLKV ; WDHQGVELTS ; IPAHSGPISQ ; 2250: CAAALEPRPG ; GQPGSELLVV ; TVGLDGATKL ; WHPLLVCQIR ; TLQGHSGPVT ; 2300: AAAASEASGL ; LLTSDDSSVQ ; LWQIPKEADD ; SYKPRSSVAI ; TAVAWAPDGS ; 2350: MVVSGNEAGE ; LTLWQQAKAV ; ATAQAPGRVS ; HLIWYSANSF ; FVLSANENVS ; 2400: EWQVGLRKGS ; TSTSSSLHLK ; RVLQEDWGVL ; TGLGLAPDGQ ; SLILMKEDVE ; 2450: LLEMKPGSIP ; SSICRRYGVH ; SSILCTSKEY ; GLFYLQQGDS ; GLLSILEQKE ; 2500: SGEFEEILDF ; NLNLNNPNGS ; PVSITQAKPE ; SESSLLCATS ; DGMLWNLSEC ; 2550: TSEGEWIVDN ; IWQKKAKKPK ; TQTLETELSP ; HSELDFSIDC ; WIDPTNLKAQ ; 2600: QCKKIHLGSV ; TALHVLPGLL ; VTASKDRDVK ; LWERPSMQLL ; GLFRCEGPVS ; 2629: CLEPWMEPSS ; PLQLAVGDTQ ; GNLYFLSWE
Sequence Length	2629
String	P97499
Sub Unit	Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.

Uniprot	P97499
Gene Name	Tep1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:21745
Unigene	Mm.318736

Reference	1. "A mammalian telomerase-associated protein." Harrington L., McPhail T., Mar V., Zhou W., Oulton R., Bass M.B., Arruda I., Robinson M.O. Science275:973-977(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;RNA-BINDING;IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX 2. "TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family." Nakayama J., Saito M., Nakamura H., Matsuura A., Ishikawa F. Cell88:875-884(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 3. "Vaults and telomerase share a common subunit, TEP1." Kickhoefer V.A., Stephen A.G., Harrington L., Robinson M.O., Rome L.H. J. Biol. Chem.274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA-BINDING 4. "The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle." Kickhoefer V.A., Liu Y., Kong L.B., Snow B.E., Stewart P.L., Harrington L., Rome L.H. J. Cell Biol.152:157-164(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VAULT RNA LOCALIZATION/STABILIZATION;IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE

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