ELISA Kit for Mouse TAR DNA-binding protein 43

Mfr.No.	E1951m
Alternative Names	Tdp43
Categories	Elisa
Function	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division.
Specificity	Natural and recombinant Mouse TAR DNA-binding protein 43
Subcellular Location	Nucleus
Entryname	TADBP_MOUSE
Platform	PF00076
Protein Name	TAR DNA-binding protein 43
Sequence	50: MSEYIRVTED ; ENDEPIEIPS ; EDDGTVLLST ; VTAQFPGACG ; LRYRNPVSQC ; 100: MRGVRLVEGI ; LHAPDAGWGN ; LVYVVNYPKD ; NKRKMDETDA ; SSAVKVKRAV ; 150: QKTSDLIVLG ; LPWKTTEQDL ; KDYFSTFGEV ; LMVQVKKDLK ; TGHSKGFGFV ; 200: RFTEYETQVK ; VMSQRHMIDG ; RWCDCKLPNS ; KQSPDEPLRS ; RKVFVGRCTE ; 250: DMTAEELQQF ; FCQYGEVVDV ; FIPKPFRAFA ; FVTFADDKVA ; QSLCGEDLII ; 300: KGISVHISNA ; EPKHNSNRQL ; ERSGRFGGNP ; GGFGNQGGFG ; NSRGGGAGLG ; 350: NNQGGNMGGG ; MNFGAFSINP ; AMMAAAQAAL ; QSSWGMMGML ; ASQQNQSGPS ; 400: GNNQSQGSMQ ; REPNQAFGSG ; NNSYSGSNSG ; APLGWGSASN ; AGSGSGFNGG ; 414: FGSSMDSKSS ; GWGM
Sequence Length	414
String	Q921F2
Sub Unit	Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810474	E1951m	96T	$776		Add to Cart