Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
Specificity
Natural and recombinant Mouse Solute carrier family 12 member 5
Subcellular Location
Cell projection dendrite Cell membrane Multi-pass membrane protein Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses.