Neurite outgrowth inhibitor ; Nogo protein ; Kiaa0886 ; Nogo
Categories
Elisa
Function
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.
Specificity
Natural and recombinant Mouse Reticulon-4
Subcellular Location
Endoplasmic reticulum membrane Multi-pass membrane protein Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.