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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Receptor tyrosine-protein kinase erbB-4

SKU : BHE13803527

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9560m
Alternative Names	Proto-oncogene-like protein c-ErbB-4 ; Mer4
Categories	Elisa
Function	Specifically binds and is activated by neuregulins, including NRG2 and NRG3, HBEGF, BTC and NTAK. Interaction with these factors induces cell differentiation. Plays a role in the regulation of cell growth and cell proliferation. The C-terminal fragment (CTF) of isoform JMA-A CYT-2 (containing E4ICD2) can stimulate transcription in the presence of YAP1. Conflicting reports are likely due at least in part to the opposing effects of the isoform-specific and nuclear-translocated ERBB4 intracellular domains (E4ICD1 and E4ICD2). Overexpression studies in epithelium show growth inhibition using E4ICD1 and increased proliferation using E4ICD2. E4ICD2 has greater in vitro kinase activity than E4ICD1. The kinase activity is required for the nuclear translocation of E4ICD2.
Specificity	Natural and recombinant Mouse Receptor tyrosine-protein kinase erbB-4
Subcellular Location	ERBB4 intracellular domain Nucleus Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus.
Entryname	ERBB4_MOUSE
Platform	PF00757
Protein Name	Receptor tyrosine-protein kinase erbB-4
Sequence	50: MKLATGLWVW ; GSLLMAAGTV ; QPSASQSVCA ; GTENKLSSLS ; DLEQQYRALR ; 100: KYYENCEVVM ; GNLEITSIEH ; NRDLSFLRSI ; REVTGYVLVA ; LNQFRYLPLE ; 150: NLRIIRGTKL ; YEDRYALAIF ; LNYRKDGNFG ; LQELGLKNLT ; EILNGGVYVD ; 200: QNKFLCYADT ; IHWQDIVRNP ; WPSNMTLVST ; NGSSGCGRCH ; KSCTGRCWGP ; 250: TENHCQTLTR ; TVCAEQCDGR ; CYGPYVSDCC ; HRECAGGCSG ; PKDTDCFACM ; 300: NFNDSGACVT ; QCPQTFVYNP ; TTFQLEHNFN ; AKYTYGAFCV ; KKCPHNFVVD ; 350: SSSCVRACPS ; SKMEVEENGI ; KMCKPCTDIC ; PKACDGIGTG ; SLMSAQTVDS ; 400: SNIDKFINCT ; KINGNLIFLV ; TGIHGDPYNA ; IDAIDPEKLN ; VFRTVREITG ; 450: FLNIQSWPPN ; MTDFSVFSNL ; VTIGGRVLYS ; GLSLLILKQQ ; GITSLQFQSL ; 500: KEISAGNIYI ; TDNSNLCYYH ; TINWTTLFST ; INQRIVIRDN ; RRAENCTAEG ; 550: MVCNHLCSND ; GCWGPGPDQC ; LSCRRFSRGK ; ICIESCNLYD ; GEFREFENGS ; 600: ICVECDSQCE ; KMEDGLLTCH ; GPGPDNCTKC ; SHFKDGPNCV ; EKCPDGLQGA ; 650: NSFIFKYADQ ; DRECHPCHPN ; CTQGCNGPTS ; HDCIYYPWTG ; HSTLPQHART ; 700: PLIAAGVIGG ; LFILVIMALT ; FAVYVRRKSI ; KKKRALRRFL ; ETELVEPLTP ; 750: SGTAPNQAQL ; RILKETELKR ; VKVLGSGAFG ; TVYKGIWVPE ; GETVKIPVAI ; 800: KILNETTGPK ; ANVEFMDEAL ; IMASMDHPHL ; VRLLGVCLSP ; TIQLVTQLMP ; 850: HGCLLDYVHE ; HKDNIGSQLL ; LNWCVQIAKG ; MMYLEERRLV ; HRDLAARNVL ; 900: VKSPNHVKIT ; DFGLARLLEG ; DEKEYNADGG ; KMPIKWMALE ; CIHYRKFTHQ ; 950: SDVWSYGVTI ; WELMTFGGKP ; YDGIPTREIP ; DLLEKGERLP ; QPPICTIDVY ; 1000: MVMVKCWMID ; ADSRPKFKEL ; AAEFSRMARD ; PQRYLVIQGD ; DRMKLPSPND ; 1050: SKFFQNLLDE ; EDLEDMMDAE ; EYLVPQAFNI ; PPPIYTSRTR ; IDSNRNQFVY ; 1100: QDGGFATQQG ; MPMPYRATTS ; TIPEAPVAQG ; ATAEMFDDSC ; CNGTLRKPVA ; 1150: PHVQEDSSTQ ; RYSADPTVFA ; PERNPRGELD ; EEGYMTPMHD ; KPKQEYLNPV ; 1200: EENPFVSRRK ; NGDLQALDNP ; EYHSASSGPP ; KAEDEYVNEP ; LYLNTFANAL ; 1250: GSAEYMKNSV ; LSVPEKAKKA ; FDNPDYWNHS ; LPPRSTLQHP ; DYLQEYSTKY ; 1292: FYKQNGRIRP ; IVAENPEYLS ; EFSLKPGTML ; PPPPYRHRNT ; VV
Sequence Length	1292
String	Q61527
Sub Unit	Homodimer or heterodimer with each of the other ERBB receptors. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts (via PPxy motifs)with WWOX. Interacts with MUC1. Interacts (via PPxY motif 2) with YAP1 (via WW domain 1). Interacts (isoform JM-A CYT-1 and isoform JM-B CYT-1) with WWP1. Interacts (via the intracellular domains of both JM-A CYT-1 and JM-B CYT-1 isoforms) with TRIM28; the interaction does not phosphorylate TRIM28 but represses ERBB4-mediated transcriptional activity. Interacts with PRPU, DDX23, MATR3, RBM15, ILF3, U5S1, U2SURP, ITCH, HNRPU, AP2A1, NULC, LEO1, WWP2, IGHG1, HXK1, GRB7 AND ARS2 (By similarity). Interacts with CBFA2T3.

Uniprot	Q61527
Gene Name	Erbb4
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:13869
Unigene	Mm.442420

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803527	E9560m	96T	$776		Add to Cart

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