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ELISA Kit for Mouse Receptor-type tyrosine-protein kinase FLT3

SKU : BHE13805008

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0039m
Alternative Names	FL cytokine receptor ; Fetal liver kinase 2 ; FLK-2 ; Fms-like tyrosine kinase 3 ; FLT-3 ; Tyrosine-protein kinase receptor flk-2 ; CD135 ; Flk-2 ; Flt-3
Categories	Elisa
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Specificity	Natural and recombinant Mouse Receptor-type tyrosine-protein kinase FLT3
Subcellular Location	Membrane Single-pass type I membrane protein Endoplasmic reticulum lumen Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
Detection Range	31.2-2000pg/mL
Entryname	FLT3_MOUSE
Method Type	Sandwich
Platform	PF00047
Protein Name	Receptor-type tyrosine-protein kinase FLT3
Sensitivity	15.63pg/mL
Sequence	50: MRALAQRSDR ; RLLLLVVLSV ; MILETVTNQD ; LPVIKCVLIS ; HENNGSSAGK ; 100: PSSYRMVRGS ; PEDLQCTPRR ; QSEGTVYEAA ; TVEVAESGSI ; TLQVQLATPG ; 150: DLSCLWVFKH ; SSLGCQPHFD ; LQNRGIVSMA ; ILNVTETQAG ; EYLLHIQSER ; 200: ANYTVLFTVN ; VRDTQLYVLR ; RPYFRKMENQ ; DALLCISEGV ; PEPTVEWVLC ; 250: SSHRESCKEE ; GPAVVRKEEK ; VLHELFGTDI ; RCCARNALGR ; ECTKLFTIDL ; 300: NQAPQSTLPQ ; LFLKVGEPLW ; IRCKAIHVNH ; GFGLTWELED ; KALEEGSYFE ; 350: MSTYSTNRTM ; IRILLAFVSS ; VGRNDTGYYT ; CSSSKHPSQS ; ALVTILEKGF ; 400: INATSSQEEY ; EIDPYEKFCF ; SVRFKAYPRI ; RCTWIFSQAS ; FPCEQRGLED ; 450: GYSISKFCDH ; KNKPGEYIFY ; AENDDAQFTK ; MFTLNIRKKP ; QVLANASASQ ; 500: ASCSSDGYPL ; PSWTWKKCSD ; KSPNCTEEIP ; EGVWNKKANR ; KVFGQWVSSS ; 550: TLNMSEAGKG ; LLVKCCAYNS ; MGTSCETIFL ; NSPGPFPFIQ ; DNISFYATIG ; 600: LCLPFIVVLI ; VLICHKYKKQ ; FRYESQLQMI ; QVTGPLDNEY ; FYVDFRDYEY ; 650: DLKWEFPREN ; LEFGKVLGSG ; AFGRVMNATA ; YGISKTGVSI ; QVAVKMLKEK ; 700: ADSCEKEALM ; SELKMMTHLG ; HHDNIVNLLG ; ACTLSGPVYL ; IFEYCCYGDL ; 750: LNYLRSKREK ; FHRTWTEIFK ; EHNFSSYPTF ; QAHSNSSMPG ; SREVQLHPPL ; 800: DQLSGFNGNS ; IHSEDEIEYE ; NQKRLAEEEE ; EDLNVLTFED ; LLCFAYQVAK ; 850: GMEFLEFKSC ; VHRDLAARNV ; LVTHGKVVKI ; CDFGLARDIL ; SDSSYVVRGN ; 900: ARLPVKWMAP ; ESLFEGIYTI ; KSDVWSYGIL ; LWEIFSLGVN ; PYPGIPVDAN ; 950: FYKLIQSGFK ; MEQPFYATEG ; IYFVMQSCWA ; FDSRKRPSFP ; NLTSFLGCQL ; 992: AEAEEACIRT ; SIHLPKQAAP ; QQRGGLRAQS ; PQRQVKIHRE ; RS
Sequence Length	992
String	Q00342
Sub Unit	Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. One homodimer interacts with one FLT3LG molecule. Interacts with FIZ1 following ligand activation. Interacts with FES, FER and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2.

Uniprot	Q00342
Gene Name	Flt3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:14255
Unigene	Mm.194

Reference	1. "A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations." Matthews W., Jordan C.T., Wiegand G.W., Pardoll D., Lemischka I.R. Cell65:1143-1152(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Liver. 2. "Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family." Rosnet O., Marchetto S., Delapeyriere O., Birnbaum D. Oncogene6:1641-1650(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase." Maroc N., Rottapel R., Rosnet O., Marchetto S., Lavezzi C., Mannoni P., Birnbaum D., Dubreuil P. Oncogene8:909-918(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION 4. "Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors." Mackarehtschian K., Hardin J.D., Moore K.A., Boast S., Goff S.P., Lemischka I.R. Immunity3:147-161(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 5. "Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified." Maraskovsky E., Brasel K., Teepe M., Roux E.R., Lyman S.D., Shortman K., McKenna H.J. J. Exp. Med.184:1953-1962(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF DENDRITIC CELL DEVELOPMENT 6. "Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3." Wolf I., Rohrschneider L.R. J. Biol. Chem.274:21478-21484(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FIZ1;MUTAGENESIS OF LYS-645 7. "The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues." Waskow C., Liu K., Darrasse-Jeze G., Guermonprez P., Ginhoux F., Merad M., Shengelia T., Yao K., Nussenzweig M. Nat. Immunol.9:676-683(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 8. "In vivo analysis of dendritic cell development and homeostasis." Liu K., Victora G.D., Schwickert T.A., Guermonprez P., Meredith M.M., Yao K., Chu F.F., Randolph G.J., Rudensky A.Y., Nussenzweig M. Science324:392-397(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 9. "Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells." Eidenschenk C., Crozat K., Krebs P., Arens R., Popkin D., Arnold C.N., Blasius A.L., Benedict C.A., Moresco E.M., Xia Y., Beutler B. Proc. Natl. Acad. Sci. U.S.A.107:9759-9764(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF DENDRITIC CELL DEVELOPMENT 10. "Further activation of FLT3 mutants by FLT3 ligand." Zheng R., Bailey E., Nguyen B., Yang X., Piloto O., Levis M., Small D. Oncogene30:4004-4014(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;DOMAIN;ENZYME REGULATION 11. "The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor." Smith C.J., Berry D.M., McGlade C.J. J. Cell Sci.126:1366-1380(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF115 AND RNF126

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