Probable helicase, which may be involved in RNA maturation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress.
Specificity
Natural and recombinant Mouse Probable helicase senataxin
Subcellular Location
Nucleus nucleoplasm Nucleus nucleolus Cytoplasm Most abundant in the nucleus (By similarity). Detected in granules (By similarity). Colocalized in cycling cells with FBL in the nucleolus (By similarity). May be detected in the nucleolus only in cycling cells.