Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1.
Specificity
Natural and recombinant Mouse Lymphoid enhancer-binding factor 1
Subcellular Location
Nucleus Found in nuclear bodies upon PIASG binding.
Binds the armadillo repeat of CTNNB1 and forms a stable complex. Binds TLE1, THOC4, MDFI and MDFIC (By similarity). Interacts with NLK (By similarity). Interacts with EP300 and PIASG.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNB1;MUTAGENESIS OF ASP-19; GLU-20; PHE-24; ASP-26 AND GLU-27
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION;INTERACTION WITH PIASG;LOCATION IN NUCLEAR BODIES
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9.
"High resolution NMR structure of the LEF-1 HMG domain complexed with its cognate DNA." Li X., Love J.J., Case D.A., Wright P.E. Submitted (1998-10) to the PDB data bank
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Reviews of ELISA Kit for Mouse Lymphoid enhancer-binding factor 1