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ELISA Kit for Mouse Integrin alpha-5

SKU : BHE13805869

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9148m
Alternative Names	CD49 antigen-like family member E ; Fibronectin receptor subunit alpha ; Integrin alpha-F ; VLA-5 ; CD49e
Categories	Elisa
Function	Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. May play a role in the survival of adult skeletal muscle.
Specificity	Natural and recombinant Mouse Integrin alpha-5
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	0.156-10ng/mL
Entryname	ITA5_MOUSE
Method Type	Sandwich
Platform	PF01839
Protein Name	Integrin alpha-5
Sensitivity	0.084ng/mL
Sequence	50: MGSWTPRSPR ; SPLHAVLLRW ; GPRRLPPLLP ; LLLLLWPPPL ; QVGGFNLDAE ; 100: APAVLSGPPG ; SLFGFSVEFY ; RPGRDGVSVL ; VGAPKANTSQ ; PGVLQGGAVY ; 150: VCPWGTSPIQ ; CTTIQFDSKG ; SRILESSLYS ; AKGEEPVEYK ; SLQWFGATVR ; 200: AHGSSILACA ; PLYSWRTEKD ; PQNDPVGTCY ; LSTENFTRIL ; EYAPCRSDFG ; 250: SAAGQGYCQG ; GFSAEFTKTG ; RVVLGGPGSY ; FWQGQILSAT ; QEQISESYYP ; 300: EYLINPVQGQ ; LQTRQASSVY ; DDSYLGYSVA ; VGEFSGDDTE ; DFVAGVPKGN ; 350: LTYGYVTVLN ; GSDIHSLYNV ; SGEQMASYFG ; YAVAATDTNG ; DGLDDLLVGA ; 400: PLLMERTADG ; RPQEVGRVYI ; YLQRPAGIDP ; TPTLTLTGQD ; EFSRFGSSLT ; 450: PLGDLDQDGY ; NDVAIGAPFG ; GEAQQGVVFI ; FPGGPGGLST ; KPSQVLQPLW ; 500: AAGRTPDFFG ; SALRGGRDLD ; GNGYPDLIVG ; SFGVDKALVY ; RGRPIISASA ; 550: SLTIFPSMFN ; PEERSCSLEG ; NPVSCINLSF ; CLNASGKHVP ; NSIGFEVELQ ; 600: LDWQKQKGGV ; RRALFLTSKQ ; ATLTQTLLIQ ; NGAREDCREM ; KIYLRNESEF ; 650: RDKLSPIHIA ; LNFSLDPKAP ; MDSHGLRPVL ; HYQSKSRIED ; KAQILLDCGE ; 700: DNICVPDLQL ; DVYGEKKHVY ; LGDKNALNLT ; FHAQNLGEGG ; AYEAELRVTA ; 750: PLEAEYSGLV ; RHPGNFSSLS ; CDYFAVNQSR ; QLVCDLGNPM ; KAGTSLWGGL ; 800: RFTVPHLQDT ; KKTIQFDFQI ; LSKNLNNSQS ; NVVSFPLSVE ; AQAQVSLNGV ; 850: SKPEAVIFPV ; SDWNPQDQPQ ; KEEDLGPAVH ; HVYELINQGP ; SSISQGVLEL ; 900: SCPQALEGQQ ; LLYVTKVTGL ; SNCTSNYTPN ; SQGLELDPET ; SPHHLQKREA ; 950: PGRSSTASGT ; QVLKCPEAKC ; FRLRCEFGPL ; HRQESRSLQL ; HFRVWAKTFL ; 1000: QREYQPFSLQ ; CEAVYEALKM ; PYQILPRQLP ; QKKLQVATAV ; QWTKAEGSNG ; 1050: VPLWIIILAI ; LFGLLLLGLL ; IYVLYKLGFF ; KRSLPYGTAM ; EKAQLKPPAT ; 1053: SDA
Sequence Length	1053
String	P11688
Sub Unit	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with NISCH. Interacts with HPS5 (By similarity). Interacts with RAB21 and COMP.

Uniprot	P11688
Gene Name	Itga5
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16402
Unigene	Mm.16234

Reference	1. Morrisey E., Dutt P., Patel V. Submitted (1994-04) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Bone marrow. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II." Holers V.M., Ruff T.G., Parks D.L., McDonald J.A., Ballard L.L., Brown E.J. J. Exp. Med.169:1589-1605(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 645-1053 strain: BALB/c. 4. "Embryonic mesodermal defects in alpha 5 integrin-deficient mice." Yang J.T., Rayburn H., Hynes R.O. Development119:1093-1105(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 5. "Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration." Alahari S.K., Lee J.W., Juliano R.L. J. Cell Biol.151:1141-1154(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NISCH strain: ICR. tissue: Brain. 6. "A membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin." Alahari S.K., Nasrallah H. Biochem. J.377:449-457(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NISCH 7. "The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK." Alahari S.K., Reddig P.J., Juliano R.L. EMBO J.23:2777-2788(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NISCH 8. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation." Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B. Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-300; ASN-310; ASN-596; ASN-612; ASN-675; ASN-678 AND ASN-685 tissue: Myoblast. 9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-185; ASN-596; ASN-612; ASN-678; ASN-715; ASN-727 AND ASN-876

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