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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Hypoxia-inducible factor 3-alpha

SKU : BHE13805846

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10271m
Alternative Names	Basic-helix-loop-helix-PAS protein MOP7 ; HIF3-alpha-1 ; Inhibitory PAS domain protein ; IPAS ; Member of PAS protein 7 ; Neonatal and embryonic PAS protein ; Mop7 ; Nepas
Categories	Elisa
Function	Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 2 has a dominant-negative function of inactivating HIF1-mediated transcription. Isoform 2 attenuates the binding of HIF1 to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 2, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 2 increases and thereby secures an inhibition of HIF1A activity (By similarity). May be a negative regulator of hypoxia-inducible gene expression in the kidney. May be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea.
Specificity	Natural and recombinant Mouse Hypoxia-inducible factor 3-alpha
Subcellular Location	Nucleus Cytoplasm
Detection Range	78-5000pg/mL
Entryname	HIF3A_MOUSE
Method Type	Sandwich
Platform	PF11413
Protein Name	Hypoxia-inducible factor 3-alpha
Sensitivity	39.2pg/mL
Sequence	50: MDWDQDRSNT ; ELRKEKSRDA ; ARSRRSQETE ; VLYQLAHTLP ; FARGVSAHLD ; 100: KASIMRLTIS ; YLRMHRLCAA ; GEWNQVEKGG ; EPLDACYLKA ; LEGFVMVLTA ; 150: EGDMAYLSEN ; VSKHLGLSQL ; ELIGHSIFDF ; IHPCDQEELQ ; DALTPRPNLS ; 200: KKKLEAPTER ; HFSLRMKSTL ; TSRGRTLNLK ; AATWKVLHCS ; GHMRAYKPPA ; 250: QTSPAGSPRS ; EPPLQCLVLI ; CEAIPHPASL ; EPPLGRGAFL ; SRHSLDMKFT ; 300: YCDERIAEVA ; GYSPDDLIGC ; SAYEYIHALD ; SDAVSRSIHT ; LLSKGQAVTG ; 350: QYRFLARTGG ; YLWTQTQATV ; VSGGRGPQSE ; SIICVHFLIS ; RVEETGVVLS ; 400: LEQTEQHTRR ; PPRLSASSQK ; GIPGNSVDSP ; APRILAFLHP ; PALSEASLAA ; 450: DPRRFCSPDL ; RRLMAPILDG ; PPPAATPSTP ; QATRRPQSPL ; PADLPDKLTV ; 500: GLENAHRLST ; AQKNKTVETD ; LDIAQDPDTL ; DLEMLAPYIS ; MDDDFQLNSS ; 550: EQLPKVHRRP ; PRVARRPRAR ; SFHGLSPPIP ; EPSLLPRWGS ; DPRLNCSSPS ; 600: RGDRPTASLM ; PGTRKRALAQ ; SSEDKGLELL ; ETKPPKRSPR ; LEPGSFLLPP ; 650: LSLSFLLQGR ; QLPGNQQDPR ; APLVHSHEPL ; GLAPSLLSLC ; QHEETVQPRN ; 662: RFPPAAGLGQ ; TH
Sequence Length	662
String	Q0VBL6
Sub Unit	Heterodimerizes with ARNT. Interacts via the oxygen-dependent degradation domain (ODD) with the beta domain of VHL.

Uniprot	Q0VBL6
Gene Name	Hif3a
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:53417
Unigene	Mm.135110

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805846	E10271m	96T	$776		Add to Cart

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