Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.
Specificity
Natural and recombinant Mouse Gamma-synuclein
Subcellular Location
Cytoplasm perinuclear region Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.