Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation.
Specificity
Natural and recombinant Mouse Cytochrome P450 1A2
Subcellular Location
Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein