Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Specificity
Natural and recombinant Human V-set domain-containing T-cell activation inhibitor 1
Subcellular Location
Cell membrane Single-pass type I membrane protein Expressed at the cell surface. A soluble form has also been detected.