Melanoma differentiation-associated protein 9 ; MDA-9 ; Pro-TGF-alpha cytoplasmic domain-interacting protein 18 ; TACIP18 ; Scaffold protein Pbp1 ; Syndecan-binding protein 1 ; MDA9 ; SYCL
Categories
Elisa
Function
Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Specificity
Natural and recombinant Human Syntenin-1
Subcellular Location
Cell junction focal adhesion Cell junction adherens junction Cell membrane Peripheral membrane protein Endoplasmic reticulum membrane Peripheral membrane protein Nucleus Melanosome Cytoplasm cytosol Cytoplasm cytoskeleton Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.