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ELISA Kit for Human Switch-associated protein 70

SKU : BHE13810573

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3416h
Alternative Names	KIAA0640 ; HSPC321
Categories	Elisa
Function	Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Specificity	Natural and recombinant Human Switch-associated protein 70
Subcellular Location	Cytoplasm Cell membrane Nucleus Cell projection lamellipodium In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
Detection Range	0.156-10ng/ml
Entryname	SWP70_HUMAN
Method Type	Sandwich
Platform	PF00169
Protein Name	Switch-associated protein 70
Sensitivity	0.082ng/mL
Sequence	50: MGSLKEELLK ; AIWHAFTALD ; QDHSGKVSKS ; QLKVLSHNLC ; TVLKVPHDPV ; 100: ALEEHFRDDD ; EGPVSNQGYM ; PYLNRFILEK ; VQDNFDKIEF ; NRMCWTLCVK ; 150: KNLTKNPLLI ; TEEDAFKIWV ; IFNFLSEDKY ; PLIIVSEEIE ; YLLKKLTEAM ; 200: GGGWQQEQFE ; HYKINFDDSK ; NGLSAWELIE ; LIGNGQFSKG ; MDRQTVSMAI ; 250: NEVFNELILD ; VLKQGYMMKK ; GHRRKNWTER ; WFVLKPNIIS ; YYVSEDLKDK ; 300: KGDILLDENC ; CVESLPDKDG ; KKCLFLVKCF ; DKTFEISASD ; KKKKQEWIQA ; 350: IHSTIHLLKL ; GSPPPHKEAR ; QRRKELRKKQ ; LAEQEELERQ ; MKELQAANES ; 400: KQQELEAVRK ; KLEEAASRAA ; EEEKKRLQTQ ; VELQARFSTE ; LEREKLIRQQ ; 450: MEEQVAQKSS ; ELEQYLQRVR ; ELEDMYLKLQ ; EALEDERQAR ; QDEETVRKLQ ; 500: ARLLEEESSK ; RAELEKWHLE ; QQQAIQTTEA ; EKQELENQRV ; LKEQALQEAM ; 550: EQLEQLELER ; KQALEQYEEV ; KKKLEMATNK ; TKSWKDKVAH ; HEGLIRLIEP ; 585: GSKNPHLITN ; WGPAAFTEAE ; LEEREKNWKE ; KKTTE
Sequence Length	585
String	Q9UH65
Sub Unit	The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.

Uniprot	Q9UH65
Gene Name	SWAP70
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:23075
Unigene	Hs.153026

Reference	1. "Association of SWAP-70 with the B cell antigen receptor complex." Masat L., Caldwell J., Armstrong R., Khoshnevisan H., Jessberger R., Herndier B., Wabl M., Ferrick D. Proc. Natl. Acad. Sci. U.S.A.97:2180-2184(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION;MUTAGENESIS OF TRP-297 2. "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency." Rapalus L., Minegishi Y., Lavoie A., Cunningham-Rundles C., Conley M.E. Clin. Immunol.101:270-275(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-505 3. "Human SWAP-70 homolog." Monz D.W., Comtesse N.E., Heckel D. Submitted (1999-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLU-505 4. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res.5:169-176(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLU-505 tissue: Brain. 5. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.more... Submitted (2005-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-505 6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Skin. 7. "Human partial CDS from CD34+ stem cells." Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z. Submitted (1999-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 355-543 tissue: Umbilical cord blood. 8. "SWAP-70 identifies a transitional subset of actin filaments in motile cells." Hilpelae P., Oberbanscheidt P., Hahne P., Hund M., Kalhammer G., Small J.V., Baehler M. Mol. Biol. Cell14:3242-3253(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF 223-ARG-ARG-224; ARG-230 AND 526-MET--GLU-585 9. "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 10. "Solution structure of the PH domain of KIAA0640 protein from human." RIKEN structural genomics initiative (RSGI) Submitted (2006-10) to the PDB data bank [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 211-312

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