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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Smoothelin-like protein 1

SKU : BHE13808329

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2278h
Categories	Elisa
Function	Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity.
Specificity	Natural and recombinant Human Smoothelin-like protein 1
Subcellular Location	Cytoplasm myofibril Cytoplasm myofibril sarcomere I band Cytoplasm myofibril sarcomere M line Nucleus Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus.
Detection Range	78-5000pg/mL
Entryname	SMTL1_HUMAN
Method Type	Sandwich
Platform	PF00307
Protein Name	Smoothelin-like protein 1
Sensitivity	39.5pg/mL
Sequence	50: MEQKEGKLSE ; DGTTVSPAAD ; NPEMSGGGAP ; AEETKGTAGK ; AINEGPPTES ; 100: GKQEKAPAED ; GMSAELQGEA ; NGLDEVKVES ; QREAGGKEDA ; EAELKKEDGE ; 150: KEETTVGSQE ; MTGRKEETKS ; EPKEAEEKES ; TLASEKQKAE ; EKEAKPESGQ ; 200: KADANDRDKP ; EPKATVEEED ; AKTASQEETV ; VEDEAKAEPK ; EPDGKEEAKH ; 250: GAKEEADEPG ; SPSEEQEQDV ; EKEPEGGAGV ; IPSSPEEWPE ; SPTGEGHNLS ; 300: TDGLGPDCVA ; SGQTSPSASE ; SSPSDVPQSP ; PESPSSGEKK ; EKAPERRVSA ; 350: PARPRGPRAQ ; NRKAIVDKFG ; GAASGPTALF ; RNTKAAGAAI ; GGVKNMLLEW ; 400: CRAMTKKYEH ; VDIQNFSSSW ; SSGMAFCALI ; HKFFPDAFDY ; AELDPAKRRH ; 450: NFTLAFSTAE ; KLADCAQLLD ; VDDMVRLAVP ; DSKCVYTYIQ ; ELYRSLVQKG ; 457: LVKTKKK
Sequence Length	457
String	A8MU46
Sub Unit	Interacts with PPP1R12A.

Uniprot	A8MU46
Gene Name	SMTNL1
Immunogen Species	Homo Sapiens (Human)
Unigene	Hs.68756

Reference	1. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.more... Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 2. "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle." Wooldridge A.A., Fortner C.N., Lontay B., Akimoto T., Neppl R.L., Facemire C., Datto M.B., Kwon A., McCook E., Li P., Wang S., Thresher R.J., Miller S.E., Perriard J.C., Gavin T.P., Hickner R.C., Coffman T.M., Somlyo A.V., Yan Z., Haystead T.A.more... J. Biol. Chem.283:11850-11859(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY 3. "Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy." Lontay B., Bodoor K., Weitzel D.H., Loiselle D., Fortner C., Lengyel S., Zheng D., Devente J., Hickner R., Haystead T.A. J. Biol. Chem.285:29357-29366(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808329	E2278h	96T	$736		Add to Cart

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