Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
Specificity
Natural and recombinant Human Regulator of G-protein signaling 3
Subcellular Location
Cytoplasm Nucleus Cell membrane Peripheral membrane protein Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear.