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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Receptor tyrosine-protein kinase erbB-4

SKU : BHE13803620

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9560h
Alternative Names	Proto-oncogene-like protein c-ErbB-4 ; Tyrosine kinase-type cell surface receptor HER4 ; p180erbB4 ; HER4
Categories	Elisa
Function	Specifically binds and is activated by neuregulins, including NRG2 and NRG3, HBEGF, BTC and NTAK. Interaction with these factors induces cell differentiation. Plays a role in the regulation of cell growth and cell proliferation. Not activated by EGF, TGF-A, and AREGAREGB. The C-terminal fragment (CTF) of isoform JMA-A CYT-2 (containing E4ICD2) can stimulate transcription in the presence of YAP1. Conflicting reports are likely due at least in part to the opposing effects of the isoform-specific and nuclear-translocated ERBB4 intracellular domains (E4ICD1 and E4ICD2). Overexpression studies in epithelium show growth inhibition using E4ICD1 and increased proliferation using E4ICD2. E4ICD2 has greater in vitro kinase activity than E4ICD1. The kinase activity is required for the nuclear translocation of E4ICD2.
Specificity	Natural and recombinant Human Receptor tyrosine-protein kinase erbB-4
Subcellular Location	ERBB4 intracellular domain Nucleus Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus.
Entryname	ERBB4_HUMAN
Platform	PF00757
Protein Name	Receptor tyrosine-protein kinase erbB-4
Sequence	50: MKPATGLWVW ; VSLLVAAGTV ; QPSDSQSVCA ; GTENKLSSLS ; DLEQQYRALR ; 100: KYYENCEVVM ; GNLEITSIEH ; NRDLSFLRSV ; REVTGYVLVA ; LNQFRYLPLE ; 150: NLRIIRGTKL ; YEDRYALAIF ; LNYRKDGNFG ; LQELGLKNLT ; EILNGGVYVD ; 200: QNKFLCYADT ; IHWQDIVRNP ; WPSNLTLVST ; NGSSGCGRCH ; KSCTGRCWGP ; 250: TENHCQTLTR ; TVCAEQCDGR ; CYGPYVSDCC ; HRECAGGCSG ; PKDTDCFACM ; 300: NFNDSGACVT ; QCPQTFVYNP ; TTFQLEHNFN ; AKYTYGAFCV ; KKCPHNFVVD ; 350: SSSCVRACPS ; SKMEVEENGI ; KMCKPCTDIC ; PKACDGIGTG ; SLMSAQTVDS ; 400: SNIDKFINCT ; KINGNLIFLV ; TGIHGDPYNA ; IEAIDPEKLN ; VFRTVREITG ; 450: FLNIQSWPPN ; MTDFSVFSNL ; VTIGGRVLYS ; GLSLLILKQQ ; GITSLQFQSL ; 500: KEISAGNIYI ; TDNSNLCYYH ; TINWTTLFST ; INQRIVIRDN ; RKAENCTAEG ; 550: MVCNHLCSSD ; GCWGPGPDQC ; LSCRRFSRGR ; ICIESCNLYD ; GEFREFENGS ; 600: ICVECDPQCE ; KMEDGLLTCH ; GPGPDNCTKC ; SHFKDGPNCV ; EKCPDGLQGA ; 650: NSFIFKYADP ; DRECHPCHPN ; CTQGCNGPTS ; HDCIYYPWTG ; HSTLPQHART ; 700: PLIAAGVIGG ; LFILVIVGLT ; FAVYVRRKSI ; KKKRALRRFL ; ETELVEPLTP ; 750: SGTAPNQAQL ; RILKETELKR ; VKVLGSGAFG ; TVYKGIWVPE ; GETVKIPVAI ; 800: KILNETTGPK ; ANVEFMDEAL ; IMASMDHPHL ; VRLLGVCLSP ; TIQLVTQLMP ; 850: HGCLLEYVHE ; HKDNIGSQLL ; LNWCVQIAKG ; MMYLEERRLV ; HRDLAARNVL ; 900: VKSPNHVKIT ; DFGLARLLEG ; DEKEYNADGG ; KMPIKWMALE ; CIHYRKFTHQ ; 950: SDVWSYGVTI ; WELMTFGGKP ; YDGIPTREIP ; DLLEKGERLP ; QPPICTIDVY ; 1000: MVMVKCWMID ; ADSRPKFKEL ; AAEFSRMARD ; PQRYLVIQGD ; DRMKLPSPND ; 1050: SKFFQNLLDE ; EDLEDMMDAE ; EYLVPQAFNI ; PPPIYTSRAR ; IDSNRSEIGH ; 1100: SPPPAYTPMS ; GNQFVYRDGG ; FAAEQGVSVP ; YRAPTSTIPE ; APVAQGATAE ; 1150: IFDDSCCNGT ; LRKPVAPHVQ ; EDSSTQRYSA ; DPTVFAPERS ; PRGELDEEGY ; 1200: MTPMRDKPKQ ; EYLNPVEENP ; FVSRRKNGDL ; QALDNPEYHN ; ASNGPPKAED ; 1250: EYVNEPLYLN ; TFANTLGKAE ; YLKNNILSMP ; EKAKKAFDNP ; DYWNHSLPPR ; 1300: STLQHPDYLQ ; EYSTKYFYKQ ; NGRIRPIVAE ; NPEYLSEFSL ; KPGTVLPPPP ; 1308: YRHRNTVV
Sequence Length	1308
String	Q15303
Sub Unit	Homodimer or heterodimer with another ERBB family member (By similarity). Interacts with CBFA2T3 (By similarity). Interacts with DLG2 (via its PDZ domain), DLG3 (via its PDZ domain), DLG4 (via its PDZ domain) and SNTB2 (via its PDZ domain). Interacts with MUC1. Interacts (via its PPxy motifs) with WWOX. Interacts (via the PPxY motif 3 of isoform JM-A CYT-2) with YAP1 (via the WW domain 1 of isoform 1). Interacts (isoform JM-A CYT-1 and isoform JM-B CYT-1) with WWP1. Interacts (via its intracellular domain) with TRIM28. Interacts (via the intracellular domains of both CYT-1 and CYT-2 isoforms) with KAP1; the interaction does not phosphorylate KAP1 but represses ERBB4-mediated transcriptional activity. Interacts with PRPU, DDX23, MATR3, RBM15, ILF3, KAP1, U5S1, U2SURP, ITCH, HNRPU, AP2A1, NULC, LEO1, WWP2, IGHG1, HXK1, GRB7 AND ARS2.

Uniprot	Q15303
Gene Name	ERBB4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2066
Unigene	Hs.390729

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803620	E9560h	96T	$736		Add to Cart

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