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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Protein S100-A8

SKU : BHE13808756

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1792h
Alternative Names	Calgranulin-A ; Calprotectin L1L subunit ; Cystic fibrosis antigen ; CFAG ; Leukocyte L1 complex light chain ; Migration inhibitory factor-related protein 8 ; MRP-8 ; S100 calcium-binding protein A8 ; Urinary stone protein band A ; CAGA ; CFAG ; MRP8
Categories	Elisa
Function	Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.
Specificity	Natural and recombinant Human Protein S100-A8
Subcellular Location	Secreted Cytoplasm Cytoplasm cytoskeleton Cell membrane Peripheral membrane protein Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation.
Detection Range	0.312-20ng/mL
Entryname	S10A8_HUMAN
Method Type	Sandwich
Platform	PF01023
Protein Name	Protein S100-A8
Sensitivity	0.195ng/mL
Sequence	50: MLTELEKALN ; SIIDVYHKYS ; LIKGNFHAVY ; RDDLKKLLET ; ECPQYIRKKG ; 93: ADVWFKELDI ; NTDGAVNFQE ; FLILVIKMGV ; AAHKKSHEES ; HKE
Sequence Length	93
String	P05109
Sub Unit	Homodimer. Heterotetramer with S100A9. Component of the heterotetrameric calprotectin complex containing two copies each of S100A8 and S100A9. Interacts with AGER and with the heterodimeric complex formed by TLR4 and LY96. Interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin interacts with ANXA6 and associates with tubulin filaments in activated monocytes. May interact with components of the intermediate filaments in monocytes and epithelial cells.

Uniprot	P05109
Gene Name	S100A8
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6279
Unigene	Hs.416073

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808756	E1792h	96T	$736		Add to Cart

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