Probable helicase, which may be involved in RNA maturation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress.
Specificity
Natural and recombinant Human Probable helicase senataxin
Subcellular Location
Nucleus nucleoplasm Nucleus nucleolus Cytoplasm May be detected in the nucleolus only in cycling cells (By similarity). Most abundant in the nucleus. Detected in granules. Colocalized in cycling cells with FBL in the nucleolus.