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ELISA Kit for Human Plectin

SKU : BHE13809113

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15105h
Alternative Names	Hemidesmosomal protein 1 ; HD1 ; Plectin-1 ; PLEC1
Categories	Elisa
Function	Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintainance of myofibers integrity.
Specificity	Natural and recombinant Human Plectin
Subcellular Location	Cytoplasm cytoskeleton Cell junction hemidesmosome
Detection Range	0.312-20ng/mL
Entryname	PLEC_HUMAN
Method Type	Sandwich
Platform	PF00307
Protein Name	Plectin
Sensitivity	0.099ng/ml
Sequence	50: MVAGMLMPRD ; QLRAIYEVLF ; REGVMVAKKD ; RRPRSLHPHV ; PGVTNLQVMR ; 100: AMASLRARGL ; VRETFAWCHF ; YWYLTNEGIA ; HLRQYLHLPP ; EIVPASLQRV ; 150: RRPVAMVMPA ; RRTPHVQAVQ ; GPLGSPPKRG ; PLPTEEQRVY ; RRKELEEVSP ; 200: ETPVVPATTQ ; RTLARPGPEP ; APATDERDRV ; QKKTFTKWVN ; KHLIKAQRHI ; 250: SDLYEDLRDG ; HNLISLLEVL ; SGDSLPREKG ; RMRFHKLQNV ; QIALDYLRHR ; 300: QVKLVNIRND ; DIADGNPKLT ; LGLIWTIILH ; FQISDIQVSG ; QSEDMTAKEK ; 350: LLLWSQRMVE ; GYQGLRCDNF ; TSSWRDGRLF ; NAIIHRHKPL ; LIDMNKVYRQ ; 400: TNLENLDQAF ; SVAERDLGVT ; RLLDPEDVDV ; PQPDEKSIIT ; YVSSLYDAMP ; 450: RVPDVQDGVR ; ANELQLRWQE ; YRELVLLLLQ ; WMRHHTAAFE ; ERRFPSSFEE ; 500: IEILWSQFLK ; FKEMELPAKE ; ADKNRSKGIY ; QSLEGAVQAG ; QLKVPPGYHP ; 550: LDVEKEWGKL ; HVAILEREKQ ; LRSEFERLEC ; LQRIVTKLQM ; EAGLCEEQLN ; 600: QADALLQSDV ; RLLAAGKVPQ ; RAGEVERDLD ; KADSMIRLLF ; NDVQTLKDGR ; 650: HPQGEQMYRR ; VYRLHERLVA ; IRTEYNLRLK ; AGVAAPATQV ; AQVTLQSVQR ; 700: RPELEDSTLR ; YLQDLLAWVE ; ENQHRVDGAE ; WGVDLPSVEA ; QLGSHRGLHQ ; 750: SIEEFRAKIE ; RARSDEGQLS ; PATRGAYRDC ; LGRLDLQYAK ; LLNSSKARLR ; 800: SLESLHSFVA ; AATKELMWLN ; EKEEEEVGFD ; WSDRNTNMTA ; KKESYSALMR ; 850: ELELKEKKIK ; ELQNAGDRLL ; REDHPARPTV ; ESFQAALQTQ ; WSWMLQLCCC ; 900: IEAHLKENAA ; YFQFFSDVRE ; AEGQLQKLQE ; ALRRKYSCDR ; SATVTRLEDL ; 950: LQDAQDEKEQ ; LNEYKGHLSG ; LAKRAKAVVQ ; LKPRHPAHPM ; RGRLPLLAVC ; 1000: DYKQVEVTVH ; KGDECQLVGP ; AQPSHWKVLS ; SSGSEAAVPS ; VCFLVPPPNQ ; 1050: EAQEAVTRLE ; AQHQALVTLW ; HQLHVDMKSL ; LAWQSLRRDV ; QLIRSWSLAT ; 1100: FRTLKPEEQR ; QALHSLELHY ; QAFLRDSQDA ; GGFGPEDRLM ; AEREYGSCSH ; 1150: HYQQLLQSLE ; QGAQEESRCQ ; RCISELKDIR ; LQLEACETRT ; VHRLRLPLDK ; 1200: EPARECAQRI ; AEQQKAQAEV ; EGLGKGVARL ; SAEAEKVLAL ; PEPSPAAPTL ; 1250: RSELELTLGK ; LEQVRSLSAI ; YLEKLKTISL ; VIRGTQGAEE ; VLRAHEEQLK ; 1300: EAQAVPATLP ; ELEATKASLK ; KLRAQAEAQQ ; PTFDALRDEL ; RGAQEVGERL ; 1350: QQRHGERDVE ; VERWRERVAQ ; LLERWQAVLA ; QTDVRQRELE ; QLGRQLRYYR ; 1400: ESADPLGAWL ; QDARRRQEQI ; QAMPLADSQA ; VREQLRQEQA ; LLEEIERHGE ; 1450: KVEECQRFAK ; QYINAIKDYE ; LQLVTYKAQL ; EPVASPAKKP ; KVQSGSESVI ; 1500: QEYVDLRTHY ; SELTTLTSQY ; IKFISETLRR ; MEEEERLAEQ ; QRAEERERLA ; 1550: EVEAALEKQR ; QLAEAHAQAK ; AQAEREAKEL ; QQRMQEEVVR ; REEAAVDAQQ ; 1600: QKRSIQEELQ ; QLRQSSEAEI ; QAKARQAEAA ; ERSRLRIEEE ; IRVVRLQLEA ; 1650: TERQRGGAEG ; ELQALRARAE ; EAEAQKRQAQ ; EEAERLRRQV ; QDESQRKRQA ; 1700: EVELASRVKA ; EAEAAREKQR ; ALQALEELRL ; QAEEAERRLR ; QAEVERARQV ; 1750: QVALETAQRS ; AEAELQSKRA ; SFAEKTAQLE ; RSLQEEHVAV ; AQLREEAERR ; 1800: AQQQAEAERA ; REEAERELER ; WQLKANEALR ; LRLQAEEVAQ ; QKSLAQAEAE ; 1850: KQKEEAEREA ; RRRGKAEEQA ; VRQRELAEQE ; LEKQRQLAEG ; TAQQRLAAEQ ; 1900: ELIRLRAETE ; QGEQQRQLLE ; EELARLQREA ; AAATQKRQEL ; EAELAKVRAE ; 1950: MEVLLASKAR ; AEEESRSTSE ; KSKQRLEAEA ; GRFRELAEEA ; ARLRALAEEA ; 2000: KRQRQLAEED ; AARQRAEAER ; VLAEKLAAIG ; EATRLKTEAE ; IALKEKEAEN ; 2050: ERLRRLAEDE ; AFQRRRLEEQ ; AAQHKADIEE ; RLAQLRKASD ; SELERQKGLV ; 2100: EDTLRQRRQV ; EEEILALKAS ; FEKAAAGKAE ; LELELGRIRS ; NAEDTLRSKE ; 2150: QAELEAARQR ; QLAAEEERRR ; REAEERVQKS ; LAAEEEAARQ ; RKAALEEVER ; 2200: LKAKVEEARR ; LRERAEQESA ; RQLQLAQEAA ; QKRLQAEEKA ; HAFAVQQKEQ ; 2250: ELQQTLQQEQ ; SVLDQLRGEA ; EAARRAAEEA ; EEARVQAERE ; AAQSRRQVEE ; 2300: AERLKQSAEE ; QAQARAQAQA ; AAEKLRKEAE ; QEAARRAQAE ; QAALRQKQAA ; 2350: DAEMEKHKKF ; AEQTLRQKAQ ; VEQELTTLRL ; QLEETDHQKN ; LLDEELQRLK ; 2400: AEATEAARQR ; SQVEEELFSV ; RVQMEELSKL ; KARIEAENRA ; LILRDKDNTQ ; 2450: RFLQEEAEKM ; KQVAEEAARL ; SVAAQEAARL ; RQLAEEDLAQ ; QRALAEKMLK ; 2500: EKMQAVQEAT ; RLKAEAELLQ ; QQKELAQEQA ; RRLQEDKEQM ; AQQLAEETQG ; 2550: FQRTLEAERQ ; RQLEMSAEAE ; RLKLRVAEMS ; RAQARAEEDA ; QRFRKQAEEI ; 2600: GEKLHRTELA ; TQEKVTLVQT ; LEIQRQQSDH ; DAERLREAIA ; ELEREKEKLQ ; 2650: QEAKLLQLKS ; EEMQTVQQEQ ; LLQETQALQQ ; SFLSEKDSLL ; QRERFIEQEK ; 2700: AKLEQLFQDE ; VAKAQQLREE ; QQRQQQQMEQ ; ERQRLVASME ; EARRRQHEAE ; 2750: EGVRRKQEEL ; QQLEQQRRQQ ; EELLAEENQR ; LREQLQLLEE ; QHRAALAHSE ; 2800: EVTASQVAAT ; KTLPNGRDAL ; DGPAAEAEPE ; HSFDGLRRKV ; SAQRLQEAGI ; 2850: LSAEELQRLA ; QGHTTVDELA ; RREDVRHYLQ ; GRSSIAGLLL ; KATNEKLSVY ; 2900: AALQRQLLSP ; GTALILLEAQ ; AASGFLLDPV ; RNRRLTVNEA ; VKEGVVGPEL ; 2950: HHKLLSAERA ; VTGYKDPYTG ; QQISLFQAMQ ; KGLIVREHGI ; RLLEAQIATG ; 3000: GVIDPVHSHR ; VPVDVAYRRG ; YFDEEMNRVL ; ADPSDDTKGF ; FDPNTHENLT ; 3050: YLQLLERCVE ; DPETGLCLLP ; LTDKAAKGGE ; LVYTDSEARD ; VFEKATVSAP ; 3100: FGKFQGKTVT ; IWEIINSEYF ; TAEQRRDLLR ; QFRTGRITVE ; KIIKIIITVV ; 3150: EEQEQKGRLC ; FEGLRSLVPA ; AELLESRVID ; RELYQQLQRG ; ERSVRDVAEV ; 3200: DTVRRALRGA ; NVIAGVWLEE ; AGQKLSIYNA ; LKKDLLPSDM ; AVALLEAQAG ; 3250: TGHIIDPATS ; ARLTVDEAVR ; AGLVGPEFHE ; KLLSAEKAVT ; GYRDPYTGQS ; 3300: VSLFQALKKG ; LIPREQGLRL ; LDAQLSTGGI ; VDPSKSHRVP ; LDVACARGCL ; 3350: DEETSRALSA ; PRADAKAYSD ; PSTGEPATYG ; ELQQRCRPDQ ; LTGLSLLPLS ; 3400: EKAARARQEE ; LYSELQARET ; FEKTPVEVPV ; GGFKGRTVTV ; WELISSEYFT ; 3450: AEQRQELLRQ ; FRTGKVTVEK ; VIKILITIVE ; EVETLRQERL ; SFSGLRAPVP ; 3500: ASELLASGVL ; SRAQFEQLKD ; GKTTVKDLSE ; LGSVRTLLQG ; SGCLAGIYLE ; 3550: DTKEKVSIYE ; AMRRGLLRAT ; TAALLLEAQA ; ATGFLVDPVR ; NQRLYVHEAV ; 3600: KAGVVGPELH ; EQLLSAEKAV ; TGYRDPYSGS ; TISLFQAMQK ; GLVLRQHGIR ; 3650: LLEAQIATGG ; IIDPVHSHRV ; PVDVAYQRGY ; FSEEMNRVLA ; DPSDDTKGFF ; 3700: DPNTHENLTY ; RQLLERCVED ; PETGLRLLPL ; KGAEKAEVVE ; TTQVYTEEET ; 3750: RRAFEETQID ; IPGGGSHGGS ; TMSLWEVMQS ; DLIPEEQRAQ ; LMADFQAGRV ; 3800: TKERMIIIII ; EIIEKTEIIR ; QQGLASYDYV ; RRRLTAEDLF ; EARIISLETY ; 3850: NLLREGTRSL ; REALEAESAW ; CYLYGTGSVA ; GVYLPGSRQT ; LSIYQALKKG ; 3900: LLSAEVARLL ; LEAQAATGFL ; LDPVKGERLT ; VDEAVRKGLV ; GPELHDRLLS ; 3950: AERAVTGYRD ; PYTEQTISLF ; QAMKKELIPT ; EEALRLLDAQ ; LATGGIVDPR ; 4000: LGFHLPLEVA ; YQRGYLNKDT ; HDQLSEPSEV ; RSYVDPSTDE ; RLSYTQLLRR ; 4050: CRRDDGTGQL ; LLPLSDARKL ; TFRGLRKQIT ; MEELVRSQVM ; DEATALQLRE ; 4100: GLTSIEEVTK ; NLQKFLEGTS ; CIAGVFVDAT ; KERLSVYQAM ; KKGIIRPGTA ; 4150: FELLEAQAAT ; GYVIDPIKGL ; KLTVEEAVRM ; GIVGPEFKDK ; LLSAERAVTG ; 4200: YKDPYSGKLI ; SLFQAMKKGL ; ILKDHGIRLL ; EAQIATGGII ; DPEESHRLPV ; 4250: EVAYKRGLFD ; EEMNEILTDP ; SDDTKGFFDP ; NTEENLTYLQ ; LMERCITDPQ ; 4300: TGLCLLPLKE ; KKRERKTSSK ; SSVRKRRVVI ; VDPETGKEMS ; VYEAYRKGLI ; 4350: DHQTYLELSE ; QECEWEEITI ; SSSDGVVKSM ; IIDRRSGRQY ; DIDDAIAKNL ; 4400: IDRSALDQYR ; AGTLSITEFA ; DMLSGNAGGF ; RSRSSSVGSS ; SSYPISPAVS ; 4450: RTQLASWSDP ; TEETGPVAGI ; LDTETLEKVS ; ITEAMHRNLV ; DNITGQRLLE ; 4500: AQACTGGIID ; PSTGERFPVT ; DAVNKGLVDK ; IMVDRINLAQ ; KAFCGFEDPR ; 4550: TKTKMSAAQA ; LKKGWLYYEA ; GQRFLEVQYL ; TGGLIEPDTP ; GRVPLDEALQ ; 4600: RGTVDARTAQ ; KLRDVGAYSK ; YLTCPKTKLK ; ISYKDALDRS ; MVEEGTGLRL ; 4650: LEAAAQSTKG ; YYSPYSVSGS ; GSTAGSRTGS ; RTGSRAGSRR ; GSFDATGSGF ; 4684: SMTFSSSSYS ; SSGYGRRYAS ; GSSASLGGPE ; SAVA
Sequence Length	4684
String	Q15149
Sub Unit	Homodimer or homotetramer. Interacts (via actin-binding domain) with Nesprin-3. Interacts (via CH 1 domain) with VIM (via rod region) (By similarity). Interacts with COL17A1 (via N-terminus). Interacts (via N-terminus) with DST isoform 1 (via N-terminus).

Uniprot	Q15149
Gene Name	PLEC
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5339
Unigene	Hs.434248

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