Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
Specificity
Natural and recombinant Human Placenta growth factor
Subcellular Location
Secreted The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.