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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Methylcytosine dioxygenase TET1

SKU : BHE13808833

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14778h
Alternative Names	CXXC-type zinc finger protein 6 ; Leukemia-associated protein with a CXXC domain ; Ten-eleven translocation 1 gene protein ; CXXC6 ; KIAA1676 ; LCX
Categories	Elisa
Function	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
Specificity	Natural and recombinant Human Methylcytosine dioxygenase TET1
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	TET1_HUMAN
Method Type	Sandwich
Platform	PF02008
Protein Name	Methylcytosine dioxygenase TET1
Sensitivity	0.069ng/mL
Sequence	50: MSRSRHARPS ; RLVRKEDVNK ; KKKNSQLRKT ; TKGANKNVAS ; VKTLSPGKLK ; 100: QLIQERDVKK ; KTEPKPPVPV ; RSLLTRAGAA ; RMNLDRTEVL ; FQNPESLTCN ; 150: GFTMALRSTS ; LSRRLSQPPL ; VVAKSKKVPL ; SKGLEKQHDC ; DYKILPALGV ; 200: KHSENDSVPM ; QDTQVLPDIE ; TLIGVQNPSL ; LKGKSQETTQ ; FWSQRVEDSK ; 250: INIPTHSGPA ; AEILPGPLEG ; TRCGEGLFSE ; ETLNDTSGSP ; KMFAQDTVCA ; 300: PFPQRATPKV ; TSQGNPSIQL ; EELGSRVESL ; KLSDSYLDPI ; KSEHDCYPTS ; 350: SLNKVIPDLN ; LRNCLALGGS ; TSPTSVIKFL ; LAGSKQATLG ; AKPDHQEAFE ; 400: ATANQQEVSD ; TTSFLGQAFG ; AIPHQWELPG ; ADPVHGEALG ; ETPDLPEIPG ; 450: AIPVQGEVFG ; TILDQQETLG ; MSGSVVPDLP ; VFLPVPPNPI ; ATFNAPSKWP ; 500: EPQSTVSYGL ; AVQGAIQILP ; LGSGHTPQSS ; SNSEKNSLPP ; VMAISNVENE ; 550: KQVHISFLPA ; NTQGFPLAPE ; RGLFHASLGI ; AQLSQAGPSK ; SDRGSSQVSV ; 600: TSTVHVVNTT ; VVTMPVPMVS ; TSSSSYTTLL ; PTLEKKKRKR ; CGVCEPCQQK ; 650: TNCGECTYCK ; NRKNSHQICK ; KRKCEELKKK ; PSVVVPLEVI ; KENKRPQREK ; 700: KPKVLKADFD ; NKPVNGPKSE ; SMDYSRCGHG ; EEQKLELNPH ; TVENVTKNED ; 750: SMTGIEVEKW ; TQNKKSQLTD ; HVKGDFSANV ; PEAEKSKNSE ; VDKKRTKSPK ; 800: LFVQTVRNGI ; KHVHCLPAET ; NVSFKKFNIE ; EFGKTLENNS ; YKFLKDTANH ; 850: KNAMSSVATD ; MSCDHLKGRS ; NVLVFQQPGF ; NCSSIPHSSH ; SIINHHASIH ; 900: NEGDQPKTPE ; NIPSKEPKDG ; SPVQPSLLSL ; MKDRRLTLEQ ; VVAIEALTQL ; 950: SEAPSENSSP ; SKSEKDEESE ; QRTASLLNSC ; KAILYTVRKD ; LQDPNLQGEP ; 1000: PKLNHCPSLE ; KQSSCNTVVF ; NGQTTTLSNS ; HINSATNQAS ; TKSHEYSKVT ; 1050: NSLSLFIPKS ; NSSKIDTNKS ; IAQGIITLDN ; CSNDLHQLPP ; RNNEVEYCNQ ; 1100: LLDSSKKLDS ; DDLSCQDATH ; TQIEEDVATQ ; LTQLASIIKI ; NYIKPEDKKV ; 1150: ESTPTSLVTC ; NVQQKYNQEK ; GTIQQKPPSS ; VHNNHGSSLT ; KQKNPTQKKT ; 1200: KSTPSRDRRK ; KKPTVVSYQE ; NDRQKWEKLS ; YMYGTICDIW ; IASKFQNFGQ ; 1250: FCPHDFPTVF ; GKISSSTKIW ; KPLAQTRSIM ; QPKTVFPPLT ; QIKLQRYPES ; 1300: AEEKVKVEPL ; DSLSLFHLKT ; ESNGKAFTDK ; AYNSQVQLTV ; NANQKAHPLT ; 1350: QPSSPPNQCA ; NVMAGDDQIR ; FQQVVKEQLM ; HQRLPTLPGI ; SHETPLPESA ; 1400: LTLRNVNVVC ; SGGITVVSTK ; SEEEVCSSSF ; GTSEFSTVDS ; AQKNFNDYAM ; 1450: NFFTNPTKNL ; VSITKDSELP ; TCSCLDRVIQ ; KDKGPYYTHL ; GAGPSVAAVR ; 1500: EIMENRYGQK ; GNAIRIEIVV ; YTGKEGKSSH ; GCPIAKWVLR ; RSSDEEKVLC ; 1550: LVRQRTGHHC ; PTAVMVVLIM ; VWDGIPLPMA ; DRLYTELTEN ; LKSYNGHPTD ; 1600: RRCTLNENRT ; CTCQGIDPET ; CGASFSFGCS ; WSMYFNGCKF ; GRSPSPRRFR ; 1650: IDPSSPLHEK ; NLEDNLQSLA ; TRLAPIYKQY ; APVAYQNQVE ; YENVARECRL ; 1700: GSKEGRPFSG ; VTACLDFCAH ; PHRDIHNMNN ; GSTVVCTLTR ; EDNRSLGVIP ; 1750: QDEQLHVLPL ; YKLSDTDEFG ; SKEGMEAKIK ; SGAIEVLAPR ; RKKRTCFTQP ; 1800: VPRSGKKRAA ; MMTEVLAHKI ; RAVEKKPIPR ; IKRKNNSTTT ; NNSKPSSLPT ; 1850: LGSNTETVQP ; EVKSETEPHF ; ILKSSDNTKT ; YSLMPSAPHP ; VKEASPGFSW ; 1900: SPKTASATPA ; PLKNDATASC ; GFSERSSTPH ; CTMPSGRLSG ; ANAAAADGPG ; 1950: ISQLGEVAPL ; PTLSAPVMEP ; LINSEPSTGV ; TEPLTPHQPN ; HQPSFLTSPQ ; 2000: DLASSPMEED ; EQHSEADEPP ; SDEPLSDDPL ; SPAEEKLPHI ; DEYWSDSEHI ; 2050: FLDANIGGVA ; IAPAHGSVLI ; ECARRELHAT ; TPVEHPNRNH ; PTRLSLVFYQ ; 2100: HKNLNKPQHG ; FELNKIKFEA ; KEAKNKKMKA ; SEQKDQAANE ; GPEQSSEVNE ; 2136: LNQIPSHKAL ; TLTHDNVVTV ; SPYALTHVAG ; PYNHWV
Sequence Length	2136
String	Q8NFU7
Sub Unit	Interacts with SIN3A; recruits the transcriptional co-repressor SIN3A to gene promoters.

Uniprot	Q8NFU7
Gene Name	TET1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:80312
Unigene	Hs.567594

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