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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Integrin beta-1

SKU : BHE13806089

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2224h
Alternative Names	Fibronectin receptor subunit beta ; Glycoprotein IIa ; GPIIA ; VLA-4 subunit beta ; CD29 ; FNRB ; MDF2 ; MSK12
Categories	Elisa
Function	Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alteatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
Specificity	Natural and recombinant Human Integrin beta-1
Subcellular Location	Cell membrane Single-pass type I membrane protein Melanosome Cleavage furrow Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in afew intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells.
Detection Range	15.6-1000pg/mL
Entryname	ITB1_HUMAN
Method Type	Sandwich
Platform	PF07974
Protein Name	Integrin beta-1
Sensitivity	10pg/mL
Sequence	50: MNLQPIFWIG ; LISSVCCVFA ; QTDENRCLKA ; NAKSCGECIQ ; AGPNCGWCTN ; 100: STFLQEGMPT ; SARCDDLEAL ; KKKGCPPDDI ; ENPRGSKDIK ; KNKNVTNRSK ; 150: GTAEKLKPED ; ITQIQPQQLV ; LRLRSGEPQT ; FTLKFKRAED ; YPIDLYYLMD ; 200: LSYSMKDDLE ; NVKSLGTDLM ; NEMRRITSDF ; RIGFGSFVEK ; TVMPYISTTP ; 250: AKLRNPCTSE ; QNCTSPFSYK ; NVLSLTNKGE ; VFNELVGKQR ; ISGNLDSPEG ; 300: GFDAIMQVAV ; CGSLIGWRNV ; TRLLVFSTDA ; GFHFAGDGKL ; GGIVLPNDGQ ; 350: CHLENNMYTM ; SHYYDYPSIA ; HLVQKLSENN ; IQTIFAVTEE ; FQPVYKELKN ; 400: LIPKSAVGTL ; SANSSNVIQL ; IIDAYNSLSS ; EVILENGKLS ; EGVTISYKSY ; 450: CKNGVNGTGE ; NGRKCSNISI ; GDEVQFEISI ; TSNKCPKKDS ; DSFKIRPLGF ; 500: TEEVEVILQY ; ICECECQSEG ; IPESPKCHEG ; NGTFECGACR ; CNEGRVGRHC ; 550: ECSTDEVNSE ; DMDAYCRKEN ; SSEICSNNGE ; CVCGQCVCRK ; RDNTNEIYSG ; 600: KFCECDNFNC ; DRSNGLICGG ; NGVCKCRVCE ; CNPNYTGSAC ; DCSLDTSTCE ; 650: ASNGQICNGR ; GICECGVCKC ; TDPKFQGQTC ; EMCQTCLGVC ; AEHKECVQCR ; 700: AFNKGEKKDT ; CTQECSYFNI ; TKVESRDKLP ; QPVQPDPVSH ; CKEKDVDDCW ; 750: FYFTYSVNGN ; NEVMVHVVEN ; PECPTGPDII ; PIVAGVVAGI ; VLIGLALLLI ; 798: WKLLMIIHDR ; REFAKFEKEK ; MNAKWDTGEN ; PIYKSAVTTV ; VNPKYEGK
Sequence Length	798
String	P05556
Sub Unit	Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with FGR.

Uniprot	P05556
Gene Name	ITGB1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3688
Unigene	Hs.643813

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806089	E2224h	96T	$736		Add to Cart

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