IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Specificity
Natural and recombinant Human Insulin-like growth factor-binding protein 3
Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a teary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.