Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
Specificity
Natural and recombinant Human Fatty-acid amide hydrolase 1
Subcellular Location
Endomembrane system Single-pass membrane protein Cytoplasm cytoskeleton Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.