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ELISA Kit for Human E3 ubiquitin-protein ligase TRIM22

SKU : BHE13811220

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5012h
Alternative Names	50 kDa-stimulated trans-acting factor ; RING finger protein 94 ; RING-type E3 ubiquitin transferase TRIM22 ; Staf-50 ; Tripartite motif-containing protein 22 ; RNF94 ; STAF50
Categories	Elisa
Function	Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Specificity	Natural and recombinant Human E3 ubiquitin-protein ligase TRIM22
Subcellular Location	Cytoplasm Nucleus Nucleus speckle Nucleus Cajal body Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
Detection Range	0.312-20ng/mL
Entryname	TRI22_HUMAN
Method Type	Sandwich
Platform	PF00622
Protein Name	E3 ubiquitin-protein ligase TRIM22
Sensitivity	0.11ng/mL
Sequence	50: MDFSVKVDIE ; KEVTCPICLE ; LLTEPLSLDC ; GHSFCQACIT ; AKIKESVIIS ; 100: RGESSCPVCQ ; TRFQPGNLRP ; NRHLANIVER ; VKEVKMSPQE ; GQKRDVCEHH ; 150: GKKLQIFCKE ; DGKVICWVCE ; LSQEHQGHQT ; FRINEVVKEC ; QEKLQVALQR ; 200: LIKEDQEAEK ; LEDDIRQERT ; AWKNYIQIER ; QKILKGFNEM ; RVILDNEEQR ; 250: ELQKLEEGEV ; NVLDNLAAAT ; DQLVQQRQDA ; STLISDLQRR ; LRGSSVEMLQ ; 300: DVIDVMKRSE ; SWTLKKPKSV ; SKKLKSVFRV ; PDLSGMLQVL ; KELTDVQYYW ; 350: VDVMLNPGSA ; TSNVAISVDQ ; RQVKTVRTCT ; FKNSNPCDFS ; AFGVFGCQYF ; 400: SSGKYYWEVD ; VSGKIAWILG ; VHSKISSLNK ; RKSSGFAFDP ; SVNYSKVYSR ; 450: YRPQYGYWVI ; GLQNTCEYNA ; FEDSSSSDPK ; VLTLFMAVPP ; CRIGVFLDYE ; 498: AGIVSFFNVT ; NHGALIYKFS ; GCRFSRPAYP ; YFNPWNCLVP ; MTVCPPSS
Sequence Length	498
String	Q8IYM9
Sub Unit	Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding. Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination.

Uniprot	Q8IYM9
Gene Name	TRIM22
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:10346
Unigene	Hs.501778

Reference	1. "Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression." Tissot C., Mechti N. J. Biol. Chem.270:14891-14898(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION;TISSUE SPECIFICITY;VARIANT THR-242 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASN-155 tissue: Lung. tissue: Testis. 3. "The tripartite motif family identifies cell compartments." Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A. EMBO J.20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION 4. "Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells." Obad S., Brunnstrom H., Vallon-Christersson J., Borg A., Drott K., Gullberg U. Oncogene23:4050-4059(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION 5. "Identification of TRIM22 as a RING finger E3 ubiquitin ligase." Duan Z., Gao B., Xu W., Xiong S. Biochem. Biophys. Res. Commun.374:502-506(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;AUTOUBIQUITINATION;MUTAGENESIS OF CYS-15 6. "The interferon response inhibits HIV particle production by induction of TRIM22." Barr S.D., Smiley J.R., Bushman F.D. PLoS Pathog.4:E1000007-E1000007(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;INTERACTION WITH HIV-1 GAG POLYPROTEIN;MUTAGENESIS OF CYS-15 AND CYS-18 7. "Dynamic localization of tripartite motif-containing 22 in nuclear and nucleolar bodies." Sivaramakrishnan G., Sun Y., Tan S.K., Lin V.C. Exp. Cell Res.315:1521-1532(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION 8. "B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies." Sivaramakrishnan G., Sun Y., Rajmohan R., Lin V.C. FEBS Lett.583:2093-2099(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-15; CYS-18 AND 493-VAL-CYS-494 9. "Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain." Gao B., Duan Z., Xu W., Xiong S. Hepatology50:424-433(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 10. "TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus." Eldin P., Papon L., Oteiza A., Brocchi E., Lawson T.G., Mechti N. J. Gen. Virol.90:536-545(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EMCV PROTEASE 3C 11. "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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