Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA.
Specificity
Natural and recombinant Human Cytoplasmic FMR1-interacting protein 2
Subcellular Location
Cytoplasm Cytoplasm perinuclear region Cell junction synapse synaptosome Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.
Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.