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ELISA Kit for Human Cubilin

SKU : BHE13803617

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9664h
Alternative Names	460 kDa receptor ; Intestinal intrinsic factor receptor ; Intrinsic factor-cobalamin receptor ; Intrinsic factor-vitamin B12 receptor ; IFCR
Categories	Elisa
Function	Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through intealization of APOA1 and cholesterol. Binds to LGALS3 at the mateal-fetal interface.
Specificity	Natural and recombinant Human Cubilin
Subcellular Location	Endosome membrane Peripheral membrane protein Lysosome membrane Peripheral membrane protein Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.
Detection Range	0.156-10ng/mL
Entryname	CUBN_HUMAN
Method Type	Sandwich
Platform	PF00431
Protein Name	Cubilin
Sensitivity	0.081ng/mL
Sequence	50: MMNMSLPFLW ; SLLTLLIFAE ; VNGEAGELEL ; QRQKRSINLQ ; QPRMATERGN ; 100: LVFLTGSAQN ; IEFRTGSLGK ; IKLNDEDLSE ; CLHQIQKNKE ; DIIELKGSAI ; 150: GLPQNISSQI ; YQLNSKLVDL ; ERKFQGLQQT ; VDKKVCSSNP ; CQNGGTCLNL ; 200: HDSFFCICPP ; QWKGPLCSAD ; VNECEIYSGT ; PLSCQNGGTC ; VNTMGSYSCH ; 250: CPPETYGPQC ; ASKYDDCEGG ; SVARCVHGIC ; EDLMREQAGE ; PKYSCVCDAG ; 300: WMFSPNSPAC ; TLDRDECSFQ ; PGPCSTLVQC ; FNTQGSFYCG ; ACPTGWQGNG ; 350: YICEDINECE ; INNGGCSVAP ; PVECVNTPGS ; SHCQACPPGY ; QGDGRVCTLT ; 400: DICSVSNGGC ; HPDASCSSTL ; GSLPLCTCLP ; GYTGNGYGPN ; GCVQLSNICL ; 450: SHPCLNGQCI ; DTVSGYFCKC ; DSGWTGVNCT ; ENINECLSNP ; CLNGGTCVDG ; 500: VDSFSCECTR ; LWTGALCQVP ; QQVCGESLSG ; INGSFSYRSP ; DVGYVHDVNC ; 550: FWVIKTEMGK ; VLRITFTFFR ; LESMDNCPHE ; FLQVYDGDSS ; SAFQLGRFCG ; 600: SSLPHELLSS ; DNALYFHLYS ; EHLRNGRGFT ; VRWETQQPEC ; GGILTGPYGS ; 650: IKSPGYPGNY ; PPGRDCVWIV ; VTSPDLLVTF ; TFGTLSLEHH ; DDCNKDYLEI ; 700: RDGPLYQDPL ; LGKFCTTFSV ; PPLQTTGPFA ; RIHFHSDSQI ; SDQGFHITYL ; 750: TSPSDLRCGG ; NYTDPEGELF ; LPELSGPFTH ; TRQCVYMMKQ ; PQGEQIQINF ; 800: THVELQCQSD ; SSQNYIEVRD ; GETLLGKVCG ; NGTISHIKSI ; TNSVWIRFKI ; 850: DASVEKASFR ; AVYQVACGDE ; LTGEGVIRSP ; FFPNVYPGER ; TCRWTIHQPQ ; 900: SQVILLNFTV ; FEIGSSAHCE ; TDYVEIGSSS ; ILGSPENKKY ; CGTDIPSFIT ; 950: SVYNFLYVTF ; VKSSSTENHG ; FMAKFSAEDL ; ACGEILTEST ; GTIQSPGHPN ; 1000: VYPHGINCTW ; HILVQPNHLI ; HLMFETFHLE ; FHYNCTNDYL ; EVYDTDSETS ; 1050: LGRYCGKSIP ; PSLTSSGNSL ; MLVFVTDSDL ; AYEGFLINYE ; AISAATACLQ ; 1100: DYTDDLGTFT ; SPNFPNNYPN ; NWECIYRITV ; RTGQLIAVHF ; TNFSLEEAIG ; 1150: NYYTDFLEIR ; DGGYEKSPLL ; GIFYGSNLPP ; TIISHSNKLW ; LKFKSDQIDT ; 1200: RSGFSAYWDG ; SSTGCGGNLT ; TSSGTFISPN ; YPMPYYHSSE ; CYWWLKSSHG ; 1250: SAFELEFKDF ; HLEHHPNCTL ; DYLAVYDGPS ; SNSHLLTQLC ; GDEKPPLIRS ; 1300: SGDSMFIKLR ; TDEGQQGRGF ; KAEYRQTCEN ; VVIVNQTYGI ; LESIGYPNPY ; 1350: SENQHCNWTI ; RATTGNTVNY ; TFLAFDLEHH ; INCSTDYLEL ; YDGPRQMGRY ; 1400: CGVDLPPPGS ; TTSSKLQVLL ; LTDGVGRREK ; GFQMQWFVYG ; CGGELSGATG ; 1450: SFSSPGFPNR ; YPPNKECIWY ; IRTDPGSSIQ ; LTIHDFDVEY ; HSRCNFDVLE ; 1500: IYGGPDFHSP ; RIAQLCTQRS ; PENPMQVSST ; GNELAIRFKT ; DLSINGRGFN ; 1550: ASWQAVTGGC ; GGIFQAPSGE ; IHSPNYPSPY ; RSNTDCSWVI ; RVDRNHRVLL ; 1600: NFTDFDLEPQ ; DSCIMAYDGL ; SSTMSRLART ; CGREQLANPI ; VSSGNSLFLR ; 1650: FQSGPSRQNR ; GFRAQFRQAC ; GGHILTSSFD ; TVSSPRFPAN ; YPNNQNCSWI ; 1700: IQAQPPLNHI ; TLSFTHFELE ; RSTTCARDFV ; EILDGGHEDA ; PLRGRYCGTD ; 1750: MPHPITSFSS ; ALTLRFVSDS ; SISAGGFHTT ; VTASVSACGG ; TFYMAEGIFN ; 1800: SPGYPDIYPP ; NVECVWNIVS ; SPGNRLQLSF ; ISFQLEDSQD ; CSRDFVEIRE ; 1850: GNATGHLVGR ; YCGNSFPLNY ; SSIVGHTLWV ; RFISDGSGSG ; TGFQATFMKI ; 1900: FGNDNIVGTH ; GKVASPFWPE ; NYPHNSNYQW ; TVNVNASHVV ; HGRILEMDIE ; 1950: EIQNCYYDKL ; RIYDGPSIHA ; RLIGAYCGTQ ; TESFSSTGNS ; LTFHFYSDSS ; 2000: ISGKGFLLEW ; FAVDAPDGVL ; PTIAPGACGG ; FLRTGDAPVF ; LFSPGWPDSY ; 2050: SNRVDCTWLI ; QAPDSTVELN ; ILSLDIESHR ; TCAYDSLVIR ; DGDNNLAQQL ; 2100: AVLCGREIPG ; PIRSTGEYMF ; IRFTSDSSVT ; RAGFNASFHK ; SCGGYLHADR ; 2150: GIITSPKYPE ; TYPSNLNCSW ; HVLVQSGLTI ; AVHFEQPFQI ; PNGDSSCNQG ; 2200: DYLVLRNGPD ; ICSPPLGPPG ; GNGHFCGSHA ; SSTLFTSDNQ ; MFVQFISDHS ; 2250: NEGQGFKIKY ; EAKSLACGGN ; VYIHDADSAG ; YVTSPNHPHN ; YPPHADCIWI ; 2300: LAAPPETRIQ ; LQFEDRFDIE ; VTPNCTSNYL ; ELRDGVDSDA ; PILSKFCGTS ; 2350: LPSSQWSSGE ; VMYLRFRSDN ; SPTHVGFKAK ; YSIAQCGGRV ; PGQSGVVESI ; 2400: GHPTLPYRDN ; LFCEWHLQGL ; SGHYLTISFE ; DFNLQNSSGC ; EKDFVEIWDN ; 2450: HTSGNILGRY ; CGNTIPDSID ; TSSNTAVVRF ; VTDGSVTASG ; FRLRFESSME ; 2500: ECGGDLQGSI ; GTFTSPNYPN ; PNPHGRICEW ; RITAPEGRRI ; TLMFNNLRLA ; 2550: THPSCNNEHV ; IVFNGIRSNS ; PQLEKLCSSV ; NVSNEIKSSG ; NTMKVIFFTD ; 2600: GSRPYGGFTA ; SYTSSEDAVC ; GGSLPNTPEG ; NFTSPGYDGV ; RNYSRNLNCE ; 2650: WTLSNPNQGN ; SSISIHFEDF ; YLESHQDCQF ; DVLEFRVGDA ; DGPLMWRLCG ; 2700: PSKPTLPLVI ; PYSQVWIHFV ; TNERVEHIGF ; HAKYSFTDCG ; GIQIGDSGVI ; 2750: TSPNYPNAYD ; SLTHCSSLLE ; APQGHTITLT ; FSDFDIEPHT ; TCAWDSVTVR ; 2800: NGGSPESPII ; GQYCGNSNPR ; TIQSGSNQLV ; VTFNSDHSLQ ; GGGFYATWNT ; 2850: QTLGCGGIFH ; SDNGTIRSPH ; WPQNFPENSR ; CSWTAITHKS ; KHLEISFDNN ; 2900: FLIPSGDGQC ; QNSFVKVWAG ; TEEVDKALLA ; TGCGNVAPGP ; VITPSNTFTA ; 2950: VFQSQEAPAQ ; GFSASFVSRC ; GSNFTGPSGY ; IISPNYPKQY ; DNNMNCTYVI ; 3000: EANPLSVVLL ; TFVSFHLEAR ; SAVTGSCVND ; GVHIIRGYSV ; MSTPFATVCG ; 3050: DEMPAPLTIA ; GPVLLNFYSN ; EQITDFGFKF ; SYRIISCGGV ; FNFSSGIITS ; 3100: PAYSYADYPN ; DMHCLYTITV ; SDDKVIELKF ; SDFDVVPSTS ; CSHDYLAIYD ; 3150: GANTSDPLLG ; KFCGSKRPPN ; VKSSNNSMLL ; VFKTDSFQTA ; KGWKMSFRQT ; 3200: LGPQQGCGGY ; LTGSNNTFAS ; PDSDSNGMYD ; KNLNCVWIII ; APVNKVIHLT ; 3250: FNTFALEAAS ; TRQRCLYDYV ; KLYDGDSENA ; NLAGTFCGST ; VPAPFISSGN ; 3300: FLTVQFISDL ; TLEREGFNAT ; YTIMDMPCGG ; TYNATWTPQN ; ISSPNSSDPD ; 3350: VPFSICTWVI ; DSPPHQQVKI ; TVWALQLTSQ ; DCTQNYLQLQ ; DSPQGHGNSR ; 3400: FQFCGRNASA ; VPVFYSSMST ; AMVIFKSGVV ; NRNSRMSFTY ; QIADCNRDYH ; 3450: KAFGNLRSPG ; WPDNYDNDKD ; CTVTLTAPQN ; HTISLFFHSL ; GIENSVECRN ; 3500: DFLEVRNGSN ; SNSPLLGKYC ; GTLLPNPVFS ; QNNELYLRFK ; SDSVTSDRGY ; 3550: EIIWTSSPSG ; CGGTLYGDRG ; SFTSPGYPGT ; YPNNTYCEWV ; LVAPAGRLVT ; 3600: INFYFISIDD ; PGDCVQNYLT ; LYDGPNASSP ; SSGPYCGGDT ; SIAPFVASSN ; 3623: QVFIKFHADY ; ARRPSAFRLT ; WDS
Sequence Length	3623
String	O60494
Sub Unit	Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Component of the cubam complex composed of CUBN and AMN. The cubam complex can oligomerize and form cubam trimers. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1.

Uniprot	O60494
Gene Name	CUBN
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8029
Unigene	Hs.166206

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