Cancer/testis antigen 89 ; CT89 ; Human lung cancer oncogene 6 protein ; HLC-6 ; JNK-associated leucine-zipper protein ; JLP ; Mitogen-activated protein kinase 8-interacting protein 4 ; Proliferation-inducing protein 6 ; Protein highly expressed in testis ; PHET ; Sperm surface protein ; Sperm-associated antigen 9 ; Sperm-specific protein ; Sunday driver 1 ; HSS ; KIAA0516 ; MAPK8IP4 ; SYD1 ; HLC6
Categories
Elisa
Function
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.
Specificity
Natural and recombinant Human C-Jun-amino-terminal kinase-interacting protein 4
Subcellular Location
Isoform 5 Cytoplasmic vesicle secretory vesicle acrosome Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of teary complex with MAPK8. Interacts with NFKB1.