Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Specificity
Natural and recombinant Bovine von Willebrand factor
Subcellular Location
Secreted Secreted extracellular space extracellular matrix Localized to storage granules.