Rat Atrial Natriuretic Peptide-converting Enzyme

Mfr.No.

E0974Ra

Alternative Names

Atrial natriuretic Peptide-converting enzyme;Atrial natriuretic Peptide-converting enzyme, 180 kDa soluble fragment;Atrial natriuretic Peptide-converting enzyme, activated protease fragment;Atrial natriuretic Peptide-converting enzyme, N-terminal propeptide;CORIN;Pro-ANP-converting enzyme

Reactivity

Rat

Detection Range

0.05-20ng/mL

Sample Type

Serum, Plasma, Cell culture supernatants

Assay Type

Sandwich

Assay Duration

1h 30m

Molecular Weight

122757

Kit Components

Components	Quantity
Pre-coated ELISA Plate	12 * 8 well strips x1
Standard solution	0.5ml x1
Standard diluent	3ml x1
Streptavidin-HRP	6ml x1
Stop solution	6ml x1
Substrate solution A	6ml x1
Substrate solution B	6ml x1
Wash buffer concentrate (25x)	20ml x1
Biotinylated antibody	1ml x1

Sensitivity

0.022ng/mL

Background

Serine-type endopeptidase involved in atrial natriuretic Peptide (NPPA) processing (PubMed: 17660514). Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation (By similarity). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (By similarity). Also acts as a regulator of sodium reabsorption in kidney (PubMed: 20613715). May also process pro-NPPB the B-type natriuretic Peptide (By similarity).

Gene ID	289596
UniProt ID	Q80YN4
Antigen	CORIN

Research Area

Cell Biology

Protocol

These standard curves of E0974Ra are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration	O.D.	Average	Corrected
12ng/mL	2.305	2.261	2.214
	2.216
6ng/mL	1.367	1.251	1.205
	1.136
3ng/mL	0.784	0.732	0.686
	0.68
1.5ng/mL	0.422	0.428	0.381
	0.433
0.75ng/mL	0.249	0.23	0.183
	0.21
0ng/mL	0.048	0.047	0
	0.045

Precision

We measured random samples of E0974Ra within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay	Sample	n	Mean	Standard Deviation	CV%
Intra-Assay	1	18	6.1	0.16	2.6
Intra-Assay	2	18	2.2	0.13	5.9
Intra-Assay	3	18	3.4	0.11	3.4

Storage	2-8°C

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SKU	Supplier No.	Size	Your price	Quantity
BHE12112223	E0974Ra	48T	$320		Add to Cart
BHE12112223	E0974Ra	96T	$458		Add to Cart

Rat Atrial Natriuretic Peptide-converting Enzyme - CORIN ELISA Kit

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