BHE13702729
TGF-beta receptor type-1 (TGFBR1) forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. TGFBR1 is a serine/threonine protein kinase. Mutations in TGFBR1 have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for TGFBR1.
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