Human Low Affinity Immunoglobulin Gamma Fc Region Receptor 2B

Mfr.No.

E3905Hu

Description

This sandwich kit is for the accurate quantitative detection of Human Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B (also known as FCGR2B) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates.

Alternative Names

CD antigen CD32;CD32;CD32B;CDw32;FCG2;Fc-gamma RII-b;Fc-gamma-RIIb;FCGR2;FCGR2B;FCGR2C;FcRII-b;IGFR2;IgG Fc receptor II-b;Low affinity immunoglobulin gamma Fc region receptor II-b

Reactivity

Human

Detection Range

0.3-90ng/ml

Sample Type

Serum, Plasma, Cell culture supernatants

Assay Type

Sandwich

Assay Duration

1h 30m

Molecular Weight

34044

Kit Components

Components	Quantity
Pre-coated ELISA plate	12 * 8 well strips x1
Standard solution	0.5ml x1
Standard diluent	3ml x1
Streptavidin-HRP	6ml x1
Stop solution	6ml x1
Substrate solution A	6ml x1
Substrate solution B	6ml x1
Wash buffer concentrate (25x)	20ml x1
Biotinylated antibody	1ml x1

Sensitivity

0.13ng/ml

Background

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Gene ID	2213
UniProt ID	P31994
Antigen	FCGR2B

Research Area

Immunology

Protocol

These standard curves of E3905Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration	O.D.	Average	Corrected
48ng/ml	1.716	1.736	1.691
	1.755
24ng/ml	0.953	1.006	0.961
	1.058
12ng/ml	0.432	0.524	0.479
	0.615
6ng/ml	0.227	0.248	0.203
	0.268
3ng/ml	0.101	0.117	0.072
	0.133
0ng/ml	0.035	0.045	0
	0.054

Precision

We measured random samples of E3905Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay	Sample	n	Mean	Standard Deviation	CV%
Intra-Assay	1	18	8.76	0.33	3.8
Intra-Assay	2	18	29.52	1.84	6.24
Intra-Assay	3	18	44.59	1.97	4.42

Storage	2-8°C

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SKU	Supplier No.	Size	Your price	Quantity
BHE12105343	E3905Hu	48T	$320		Add to Cart
BHE12105343	E3905Hu	96T	$458		Add to Cart

Human Low Affinity Immunoglobulin Gamma Fc Region Receptor 2B - FCGR2B ELISA Kit

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