Human Corticosteroid 11 Beta Dehydrogenase Isozyme 1

Mfr.No.

E5120Hu

Sensitivity

14.25ng/L

Detection Range

30-9000ng/L

Reactivity

Human

Assay Duration

1h 30m

Assay Type

Sandwich

Alternative Names

11-beta-HSD1;11-beta-hydroxysteroid dehydrogenase 1;11-DH;Corticosteroid 11-beta-dehydrogenase isozyme 1;CORTRD2;HDL;HSD11;HSD11B;HSD11B1;HSD11L;Short chain dehydrogenase/reductase family 26C member 1

Molecular Weight

32401

Kit Components

Components	Quantity
Pre-coated ELISA plate	12 * 8 well strips x1
Standard solution	0.5ml x1
Standard diluent	3ml x1
Streptavidin-HRP	6ml x1
Stop solution	6ml x1
Substrate solution A	6ml x1
Substrate solution B	6ml x1
Wash buffer concentrate (25x)	20ml x1
Biotinylated antibody	1ml x1

Sample Type

Serum, Cell culture supernatants, Plasma

Precision

We measured random samples of E5120Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay	Sample	n	Mean	Standard Deviation	CV%
Intra-Assay	1	18	2520.07	90.65	3.6
Intra-Assay	2	18	1871.23	119.69	6.4
Intra-Assay	3	18	777.42	49.7	6.39

Background

11beta-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It belongs to the family of short-chain dehydrogenases.

Protocol

These standard curves of E5120Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration	O.D.	Average	Corrected
4800ng/L	2.233	2.167	2.12
	2.101
2400ng/L	1.184	1.226	1.179
	1.267
1200ng/L	0.856	0.855	0.808
	0.854
600ng/L	0.418	0.437	0.39
	0.456
300ng/L	0.267	0.245	0.199
	0.224
0ng/L	0.043	0.046	0
	0.05

Gene ID	3290
UniProt ID	P28845

Research Area	Signal Transduction

Storage	2-8°C

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SKU	Supplier No.	Size	Your price	Quantity
BHE12106483	E5120Hu	48T	$320		Add to Cart
BHE12106483	E5120Hu	96T	$458		Add to Cart

Human Corticosteroid 11 Beta Dehydrogenase Isozyme 1 - HSD11B1 ELISA Kit

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