Human Cartilage Intermediate Layer Protein 1

Mfr.No.

E6610Hu

Alternative Names

Cartilage intermediate layer protein 1;Cartilage intermediate layer protein 1 C1;Cartilage intermediate layer protein 1 C2;Cartilage intermediate-layer protein;CILP;CILP-1

Reactivity

Human

Detection Range

50-10000ng/L

Sample Type

Serum, Plasma, Cell culture supernatants

Assay Type

Sandwich

Assay Duration

1h 30m

Molecular Weight

132565

Kit Components

Components	Quantity
Pre-coated ELISA Plate	12 * 8 well strips x1
Standard solution	0.5ml x1
Standard diluent	3ml x1
Streptavidin-HRP	6ml x1
Stop solution	6ml x1
Substrate solution A	6ml x1
Substrate solution B	6ml x1
Wash buffer concentrate (25x)	20ml x1
Biotinylated antibody	1ml x1

Sensitivity

26.34ng/L

Background

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

Gene ID	8483
UniProt ID	O75339
Antigen	CILP

Research Area

Signal Transduction

Protocol

These standard curves of E6610Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration	O.D.	Average	Corrected
6400ng/L	1.869	1.92	1.877
	1.971
3200ng/L	1.154	1.03	0.987
	0.906
1600ng/L	0.609	0.517	0.474
	0.424
800ng/L	0.212	0.252	0.209
	0.293
400ng/L	0.077	0.114	0.071
	0.15
0ng/L	0.037	0.043	0
	0.048

Precision

We measured random samples of E6610Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay	Sample	n	Mean	Standard Deviation	CV%
Intra-Assay	1	18	2041.9	104.36	5.1
Intra-Assay	2	18	3509	164.79	4.7
Intra-Assay	3	18	4443.3	106.55	2.4

Storage	2-8°C

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SKU	Supplier No.	Size	Your price	Quantity
BHE12115622	E6610Hu	48T	$320		Add to Cart
BHE12115622	E6610Hu	96T	$458		Add to Cart

Human Cartilage Intermediate Layer Protein 1 - CILP ELISA Kit

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