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Tfam-Flox

SKU : BHAM00340

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200173
Description	Model Description: These mice carry loxP sites flanking exon 10-13 of Tfam gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tfam gene. Official Symbol: Tfam NCBI ID: 21780 MGI ID: 107810 Ensembl ID: ENSMUSG00000003923 Pubmed: Tfam Human Ortholog: TFAM
Nomenclature	C57BL/6JSmoc-Tfam^{tm1(flox)Smoc}
Exon	Exon 10-13
Application	Activated Pkn1 Stimulates The Transcription Of Ar (Androgen Receptor) Regulatory Genes Klk2 And Klk3 And Related Research On Mitochondrial Gene Expression
Disease	Parkinson's Disease
Disease	Nervous System Disease
KI/KO Gene	Tfam
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Slc6a3-cre mice.
Synonyms	Hmgts, mtTFA, tsHMG, AI661103

Reference	MGI:3029267 Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, Hoffer B, Cullheim S, Mohammed AH, Olson L, Larsson NG, Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30

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