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Home / Animal Model / Disease Mice

Stat3-Flox(2)

SKU : BHAM00327

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200225
Description	Model Description: These mice carry loxP sites flanking exon 18-20 of Stat3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat3 gene.While Stat3-Flox(Stock No.NM-CKO-200050)mice carrying the loxP sites flanking exon 12-14 of Stat3 gene. Official Symbol: Stat3 NCBI ID: 20848 MGI ID: 103038 Ensembl ID: ENSMUSG00000004040 Pubmed: Stat3 Human Ortholog: STAT3
Nomenclature	C57BL/6JSmoc-Stat3^{em1(flox)Smoc}
Exon	Exon 18-20
Application	Study On Microrna Correlation Between Fgfr1 Mutant Receptor Activation And Cardiac Hypertrophy
Disease	inflammatory bowel disease
Disease	Cardio-metabolic Disease
KI/KO Gene	Stat3
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tek-cre mice.
Synonyms	Aprf, AW109958, 1110034C02Rik

Reference	MGI:5698534 Kano A, Wolfgang MJ, Gao Q, Jacoby J, Chai GX, Hansen W, Iwamoto Y, Pober JS, Flavell RA, Fu XY, Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med. 2003 Nov 17;198(10):1517-25

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