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Psen1-Flox

SKU : BHAM00243

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Psen1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Psen1 gene. Official Symbol: Psen1 NCBI ID: 19164 MGI ID: 1202717 Ensembl ID: ENSMUSG00000019969 Pubmed: Psen1 Human Ortholog: PSEN1
Nomenclature	C57BL/6JSmoc-Psen1^{em1(flox)Smoc}
Exon	Exon s
Disease	Alzheimer's Disease 3
Disease	Nervous System Disease
KI/KO Gene	Psen1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Thy1-cre mice.
Synonyms	PS1, Ad3h, PS-1, S182

Reference	MGI:3702859 Dewachter I, Reverse D, Caluwaerts N, Ris L, Kuiperi C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F, Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein (V717I) transgenic mice. J Neurosci. 2002 May 1;22(9):3445-53

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